过量服用中药后急性胃扩张1例。

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1584032
Tao Zeng, Zi-Liang Chen, Yao-Hui Zhou, Wei-Qi Liu, Jian Chen, Jian-Hui Lu, Jia-Hao Lin
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引用次数: 0

摘要

急性胃扩张(AGD)是一种罕见但临床意义重大的疾病,其特征是胃异常扩大。如果不及时处理,它会导致严重的并发症,如胃坏死、穿孔和呼吸衰竭。AGD与机械性梗阻、暴饮暴食和糖尿病等全身性疾病有关。然而,过量服用中药引起的AGD尚未见报道。患者关注:一名40岁男性,有慢性消化不良病史,因反复呕吐而就诊于急诊科。入院前3天,患者自述服用中药液约3.5升(约1.1-1.3升/天)。这种缓解慢性消化不良症状的尝试未能显示出预期的治疗效果。患者否认有头痛、头晕、胸痛、心悸、腹痛或腹泻的经历。诊断:腹部CT示明显胃胀,随后内镜示幽门溃疡伴狭窄,胃潴留,慢性萎缩性胃炎,贲门松弛。实验室检查显示代谢性碱中毒、电解质失衡和组织缺氧的迹象。干预措施:患者立即接受鼻胃管减压、抗感染治疗、胃粘膜保护、液体复苏、肠外营养支持、禁食和胃肠减压。结果:在这些干预措施后,患者的症状和体征明显改善。后续CT扫描显示胃扩张改善。在4周的随访中,患者报告呕吐完全消除,并恢复正常的口服摄入。重复内镜检查显示幽门溃疡愈合,胃动力改善。在3个月的随访期间,无不良事件(如再次住院或药物不耐受)报告。结论:本病例强调了将AGD纳入中药过量食用后频繁呕吐的鉴别诊断的必要性。它强调了彻底评估以防止误诊和严重并发症的重要性。该病例还强调了在使用中药时需要谨慎,特别是对于有器质性病变或幽门梗阻的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute gastric dilatation after excessive consumption of traditional Chinese medicine: a case report.

Introduction: Acute gastric dilatation (AGD) is a rare but clinically significant condition characterized by abnormal enlargement of the stomach. It can lead to serious complications such as gastric necrosis, perforation, and respiratory failure if not promptly managed. AGD has been associated with mechanical obstructions, binge eating, and systemic conditions like diabetes mellitus. However, AGD induced by excessive consumption of traditional Chinese medicine (TCM) has not been previously reported.

Patient concerns: A 40-year-old male with a history of chronic dyspepsia presented to the emergency department with recurrent vomiting. Over the 3 days prior to admission, he self-reported consuming approximately 3.5 liters of TCM liquid (about 1.1-1.3 liters per day). This attempt to alleviate his chronic dyspepsia symptoms failed to show the expected therapeutic effect. The patient denied experiencing headache, dizziness, chest pain, palpitations, abdominal pain, or diarrhea.

Diagnosis: Abdominal CT revealed significant gastric distension, and subsequent endoscopy showed pyloric ulcer with stenosis, gastric retention, chronic atrophic gastritis, and a relaxed cardia. Laboratory investigations indicated metabolic alkalosis, electrolyte imbalances, and signs of tissue hypoxia.

Interventions: The patient was immediately managed with nasogastric tube decompression, anti-infection therapy, gastric mucosal protection, fluid resuscitation, parenteral nutritional support, fasting, and gastrointestinal decompression.

Outcomes: The patient's symptoms and signs notably improved after these interventions. A follow-up CT scan demonstrated improved gastric dilation. At a 4-week follow-up, the patient reported complete resolution of vomiting and resumed normal oral intake. Repeat endoscopy showed healed pyloric ulcers and improved gastric motility. No adverse events (e.g., rehospitalization or medication intolerance) were reported during a 3-month follow-up period.

Conclusion: This case highlights the necessity of including AGD in the differential diagnosis for patients presenting with frequent vomiting after excessive consumption of TCM. It underscores the importance of thorough evaluation to prevent misdiagnosis and severe complications. The case also emphasizes the need for caution when using TCM, especially in patients with organic lesions or pyloric obstruction.

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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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