Yu Zhang, Zhengzheng Zhang, Borja Martinez-Tellez, Xinyu Di, Alida Kindt, Isabelle Kohler, Francisco J Osuna-Prieto, Charles Clark, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R Ruiz, Lucas Jurado-Fasoli
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引用次数: 0
摘要
背景：有规律的体育锻炼显示出显著的健康益处，可能通过以强度依赖的方式调节脂质代谢。方法：在这项研究中，我们对101名久坐不动的年轻成年人进行了为期24周的监督并行随机运动干预，对18个亚类的794种血脂进行了分析。研究结果：在这里，我们证明了中等强度的运动，而不是剧烈运动，显著增加了血浆中甘油磷脂和三酰基甘油的水平。有趣的是，我们还发现了对中等强度运动的性别特异性反应，男性表现出甘油磷脂和溶血磷脂种类的升高，而女性表现出三酰基甘油种类的显著增加。甘油磷脂种类的增加与心肺健康（即vo2峰值）的改善有关。解释：重要的是，虽然传统的脂质标志物，包括总胆固醇或甘油三酯在运动干预后保持不变，但我们的研究结果表明，运动通过选择性地靶向和改变特定的脂质亚型，以强度、性别依赖的方式，部分地发挥其健康益处。资助:该研究得到了Junta de Andalucía， Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento（参考文献p18 - rd -4455，参考文献SOMM17/6107/UGR和DOC 01151）和欧洲区域发展基金（ERDF），西班牙经济和竞争力部通过Fondo de Investigación Salud Carlos III Sanitaria Instituto （PI13/01393）和PTA-12264， Retos de la Sociedad (DEP2016-79512-R)，Fundación Iberoamericana de Nutrición （FINUT）、Redes Temáticas de Investigación Cooperativa RETIC （Red SAMID RD16/0022）、阿斯利康医疗保健基金会、格拉纳达大学Propio de Investigación 2016年卓越行动：运动与健康卓越单位（UCEES）。
Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans.
Background: Regular physical exercise shows significant health-related benefits, potentially through the modulation of lipid metabolism in an intensity-dependent manner.
Methods: In this study, we profiled 794 plasma lipid species across 18 subclasses following a 24-week supervised concurrent and randomised exercise intervention at moderate and vigorous intensities in 101 young, sedentary adults.
Findings: Here, we demonstrate that moderate-intensity exercise, but not vigorous-intensity, significantly increased plasma levels of glycerophospholipids and triacylglycerol species. Interestingly, we also identified a sex-specific response to moderate-intensity exercise, with men exhibiting elevated glycerophospholipids and lysophospholipids species, and women showing significant increases in triacylglycerols species. Increments in glycerophospholipids species were associated with improvements in cardiorespiratory fitness, i.e., VO2peak.
Interpretation: Importantly, while traditional lipid markers, including total cholesterol or triglycerides remained unchanged after the exercise intervention, our findings suggest that exercise partially exerts its health benefits by selectively targeting and modifying specific lipid subtypes in an intensity, sex-dependent manner.
Funding: The study was supported by the Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento (ref. P18-RT-4455, ref. SOMM17/6107/UGR, and DOC 01151) and European Regional Development Funds (ERDF), the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), and PTA-12264, Retos de la Sociedad (DEP2016-79512-R), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES).
EBioMedicineBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍：
eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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