基于蛋白质的磁性软体机器人的电化学-遗传规划（Adv. Sci. 27/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-07-17 DOI:10.1002/advs.202570208

Hang Zhao, Bo Yu, Dingyi Yu, Ting Ji, Kexin Nie, Jingyi Tian, Xinchen Shen, Kaiyue Zhang, Junhan Ou, Xinyi Yang, Dongfang Xiao, Qi Zhou, Wenwen Huang

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引用次数: 0

摘要

文章编号：2503404，黄文文及其同事创新了一种协同电化学-遗传方法，以定制用于活性药物递送的基于蛋白质的磁性软机器人。编码有热响应基序的丝弹性蛋白样蛋白作为机器人的水凝胶底物，由超细磁铁矿纳米晶体在配位位点原位成核增强。这种可生物降解的机器人可以通过磁力驱动在密闭空间中穿行，也可以通过热触发在目标病变上释放药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery (Adv. Sci. 27/2025)

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Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery (Adv. Sci. 27/2025)

Protein-Based Magnetic Soft Robot

In article number 2503404, Wenwen Huang and co-workers innovate a synergistic electrochemical-genetic approach to tailoring protein-based magnetic soft robot for active drug delivery. Silk-elastin-like protein encoded with thermo-responsive motifs serves as a hydrogel substrate of the robot, reinforced by ultrafine magnetite nanocrystals nucleated in situ on coordination sites. The biodegradable robot can be magnetically driven to navigate confined spaces and thermally triggered to release drug on targeted lesions.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.