胶束驱动有机合成:近十年来在水介质中合成杂环化合物和天然产物的最新进展

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-07-18 DOI:10.1039/D5RA02664D
Mohmad Muzafar Wani and Bilal A. Bhat
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引用次数: 0

摘要

胶束纳米反应器引导下的有机合成是有机化学的基础领域之一,有望以可持续的方式提供化学合成。由于它的前景,我们也被吸引到使用胶束来提高化学反应性和选择性,并探索其在天然产物和杂环化学中的新应用。迄今为止,除了金属催化的交叉偶联反应外,还没有全面的综述文章强调在胶束中发展的化学反应,提供了一系列杂环和天然产物/支架。在这篇综述中,我们记录了过去十年(2014-2024)在胶束中发展的有机反应的进展,以产生一系列杂环和天然产物为基础的支架。值得注意的是,我们已经排除了与金属催化的交叉偶联反应和胶束的一些其他方面有关的内容,因为在这些主题上写了很多重叠的评论。本文简要介绍了胶束催化、胶束中反应位点的区域以及胶束化学中使用的各种表面活性剂。我们的讨论也捕捉到胶束催化与传统有机合成相比的重要性。更重要的是,我们回顾的重点主要集中在过去十年中在获取杂环和天然产物方面完成的化学转化,以展示通过可持续方式有机合成的进步。在需要的地方,我们还捕获了表面活性剂与驱动反应所需的底物的各种相互作用,并讨论了这些杂环/天然产物在拦截关键生物途径中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Micelle-driven organic synthesis: an update on the synthesis of heterocycles and natural products in aqueous medium over the last decade

Micelle-driven organic synthesis: an update on the synthesis of heterocycles and natural products in aqueous medium over the last decade

Organic synthesis guided by micellar nanoreactors constitutes one of the fundamental fields of organic chemistry that is expected to furnish chemical synthesis in a sustainable fashion. Due to its promise, we were also attracted to using the micelles to enhance chemical reactivity and selectivity and to explore their newer applications in natural products and heterocyclic chemistry. As on date, there is no comprehensive review article that highlights the repertoire of chemical reactions developed in micelles furnishing a range heterocycles and natural products/scaffolds, barring the metal-catalyzed cross-coupling reactions. In this review, we document the last decade (2014–2024) progress of organic reactions developed in micelles to yield a range of heterocyclic and natural product-based scaffolds. Notably, we have excluded the content related to metal-catalyzed cross-coupling reactions and some other aspects of micelles due to the number of overlapping reviews written on such topics. In the current article, we briefly introduce micellar catalysis, regions of reaction sites in micelles, and various surfactants utilized in micelle chemistry. Our discussion also captures the importance of micellar catalysis compared to the conventional organic synthesis. More importantly, the focus of our review is largely on the collection of chemical transformations accomplished in the last decade in accessing heterocycles and natural products to showcase the advancement of organic synthesis through sustainable fashion. Wherever required, we have also captured the various interactions of surfactants with the substrates necessary for driving the reactions and discussed the importance of these heterocycles/natural products in intercepting the key biological pathways.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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