动力：线粒体NADPH促进氧化代谢

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-07-17 DOI:10.1016/j.chembiol.2025.06.006

Riley J. Wedan , Sara M. Nowinski

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引用次数: 0

摘要

线粒体NADPH丰富，但原因尚不清楚。在Nature Cell Biology发表的一项研究中，Kim等人1通过对线粒体脂肪酸合成（mtFAS）产物的直接量化，发现了nadk2衍生的线粒体NADPH在线粒体脂肪酸合成（mtFAS）中的重要作用。这项工作为了解NADK2、线粒体NADPH和mtFAS如何调节线粒体功能打开了大门。

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Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism

Mitochondrial NADPH is abundant, but the reason why was uncertain. In a study published in Nature Cell Biology, Kim et al.¹ identified an important role of NADK2-derived mitochondrial NADPH in mitochondrial fatty acid synthesis (mtFAS) through direct quantification of the products built by mtFAS. This work opens the door to understanding how NADK2, mitochondrial NADPH, and mtFAS regulate mitochondrial function.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.