RPL22连接核糖体生物发生，RNA剪接和对RNA聚合酶I抑制的敏感性

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-07-17 DOI:10.1016/j.chembiol.2025.06.001

Kenyon Weis , Omar Abdel-Wahab

引用次数: 0

摘要

在这一期的《细胞化学生物学》中，Fan等人1发现核糖体蛋白RPL22的突变赋予了RNA聚合酶I抑制剂的敏感性。RPL22通过剪接MDM4 mRNA调控MDM4功能和细胞死亡。这些发现将核糖体的生物发生与RPL22的RNA剪接联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition

In this issue of Cell Chemical Biology, Fan et al.¹ identify that mutations in the ribosomal protein RPL22 confer sensitivity to RNA polymerase I inhibitors. RPL22 regulates MDM4 function and cell death via splicing of the MDM4 mRNA. These findings connect ribosome biogenesis with RNA splicing through RPL22.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.