具有抗透明质酸酶活性的墨西哥红素类柠檬素。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI:10.1080/10286020.2025.2526828

Fei Zhu, Fu-Xue Liu, Ai-Yu He, Miao-Qi Shi, Xin-Lan Ren, Zeng Xu, Chen Yang, Jie Hang

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引用次数: 0

摘要

从Khaya ivorensis种子中提取80%的甲醇提取物进行植物化学研究，分离出三种未描述的墨西哥甾醇类柠檬素，ivorensisines A-C（1-3）。除高分辨率质谱外，还通过1D和2D (1H-1H COSY， HMQC和HMBC) NMR谱法对所有化合物进行了结构解析。对分离得到的各组分进行体外抗透明质酸酶活性评价。结果表明，类柠檬素3的抗透明质酸酶活性（IC50 = 8.46 μg/ml）是阳性对照药齐果酸（IC50 = 39.98 μg/ml）的3倍。

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Mexicanolide limonoids from Khaya ivorensis with anti-hyaluronidase activities.

Phytochemical study on 80% methanol extract from the seeds of Khaya ivorensis resulted into the isolation of three undescribed mexicanolide limonoids, ivorensisines A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-hyaluronidase activities. As a result, limonoid 3 exhibited significant anti-hyaluronidase activity (IC₅₀ = 8.46 μg/ml) three times more than the positive control drug oleanolic acid (IC₅₀ = 39.98 μg/ml).

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.