山参纤维根化学成分及其体外细胞毒活性研究。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-16 DOI:10.1080/10286020.2025.2529993

Zhen-Dong Liao, Rou Sun, Ren-Zhong Wang, Hong-Su Zhao, Qi Huang, Feng-Qing Xu, De-Ling Wu

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引用次数: 0

摘要

为探索羊角蕨纤维根的化学成分，共获得12个化合物，其中3个未描述化合物（1-3）和9个已知相关化合物（4-12）。它们的结构通过光谱分析确定，包括1D， 2D NMR和hremsim数据。在体外对两种人肝癌细胞（HepG2和Hep3B）进行细胞毒活性评价。其中化合物1、2、4在50 μM的高浓度下表现出抑制作用。化合物4对HepG2和Hep3B细胞株的IC50值分别为14.80±0.58 μM和10.89±0.46 μM。

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Chemical constituents from the fibrous roots of Anemarrhena asphodeloides and their in vitro cytotoxic activity.

To explore chemical constituents in the fibrous roots of Anemarrhena asphodeloides, 12 compounds were obtained, including three undescribed compounds (1-3) and nine known related compounds (4-12). Their structures were determined by spectroscopic analyses, including 1D, 2D NMR, and HRESIMS data. The cytotoxic activity of all isolates was evaluated against two human hepatoma carcinoma cells (HepG2 and Hep3B) in vitro. Among them, compounds 1, 2, and 4 exhibited inhibitory effects at high concentration of 50 μM. Compound 4 showed cytotoxic activities against HepG2 and Hep3B cell lines with the IC₅₀ values of 14.80 ± 0.58 and 10.89 ± 0.46 μM, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.