{"title":"心理资本在长期治疗乳腺癌患者药物依从性与癌症相关疲劳之间起中介作用。","authors":"Chunli Yan, Yane Chu","doi":"10.3389/fpsyt.2025.1615271","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is one of the most prevalent malignant tumors among women worldwide. Although long-term pharmacological treatment has substantially improved survival rates, it is often accompanied by psychological burdens, including cancer-related fatigue (CRF) and diminished adherence to therapy. CRF is a pervasive and debilitating symptom that adversely affects physical functioning and emotional well-being. Psychological capital (PsyCap), a construct encompassing self-efficacy, hope, optimism, and resilience, has been shown to enhance treatment engagement and promote mental health. However, its role as a potential psychological mediator between medication adherence and CRF is yet to be thoroughly investigated.</p><p><strong>Objective: </strong>To investigate the mediating role of PsyCap in the relationship between medication adherence and CRF in patients with breast cancer undergoing long-term treatment.</p><p><strong>Methods: </strong>A total of 100 breast cancer patients admitted between June 2022 and June 2024 were recruited using convenience sampling. Data from 90 valid responses were analyzed. Participants completed the PsyCap Questionnaire (PCQ-24), Self-Reported Medication Adherence Rating Scale (SR-MARS), and CRF Scale (CFS). Pearson's correlation analysis was used to assess associations among variables. A mediation analysis was conducted using the bootstrap method with 5,000 resamples.</p><p><strong>Results: </strong>The mean scores for PsyCap, medication adherence, and CRF were 86.65 ± 8.37, 5.36 ± 1.12, and 36.77 ± 5.98, respectively. PsyCap was positively correlated with medication adherence (<i>r</i> = 0.994, p < 0.05) and negatively correlated with CRF (<i>r</i> = -0.992, p < 0.05). Medication adherence was also negatively correlated with CRF (<i>r</i> = -0.994, p < 0.05). Mediation analysis confirmed that PsyCap significantly mediated the relationship between medication adherence and CRF (indirect effect = 0.357, 95% CI did not include zero), accounting for 55.68% of the total effect.</p><p><strong>Conclusion: </strong>PsyCap partially mediated the association between medication adherence and CRF. Interventions aimed at enhancing PsyCap may improve adherence and reduce CRF in breast cancer patients receiving long-term pharmacotherapy.</p>","PeriodicalId":12605,"journal":{"name":"Frontiers in Psychiatry","volume":"16 ","pages":"1615271"},"PeriodicalIF":3.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259705/pdf/","citationCount":"0","resultStr":"{\"title\":\"Psychological capital mediates the relationship between medication adherence and cancer-related fatigue in breast cancer patients undergoing long-term treatment.\",\"authors\":\"Chunli Yan, Yane Chu\",\"doi\":\"10.3389/fpsyt.2025.1615271\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Breast cancer is one of the most prevalent malignant tumors among women worldwide. Although long-term pharmacological treatment has substantially improved survival rates, it is often accompanied by psychological burdens, including cancer-related fatigue (CRF) and diminished adherence to therapy. CRF is a pervasive and debilitating symptom that adversely affects physical functioning and emotional well-being. Psychological capital (PsyCap), a construct encompassing self-efficacy, hope, optimism, and resilience, has been shown to enhance treatment engagement and promote mental health. However, its role as a potential psychological mediator between medication adherence and CRF is yet to be thoroughly investigated.</p><p><strong>Objective: </strong>To investigate the mediating role of PsyCap in the relationship between medication adherence and CRF in patients with breast cancer undergoing long-term treatment.</p><p><strong>Methods: </strong>A total of 100 breast cancer patients admitted between June 2022 and June 2024 were recruited using convenience sampling. Data from 90 valid responses were analyzed. Participants completed the PsyCap Questionnaire (PCQ-24), Self-Reported Medication Adherence Rating Scale (SR-MARS), and CRF Scale (CFS). Pearson's correlation analysis was used to assess associations among variables. A mediation analysis was conducted using the bootstrap method with 5,000 resamples.</p><p><strong>Results: </strong>The mean scores for PsyCap, medication adherence, and CRF were 86.65 ± 8.37, 5.36 ± 1.12, and 36.77 ± 5.98, respectively. PsyCap was positively correlated with medication adherence (<i>r</i> = 0.994, p < 0.05) and negatively correlated with CRF (<i>r</i> = -0.992, p < 0.05). Medication adherence was also negatively correlated with CRF (<i>r</i> = -0.994, p < 0.05). Mediation analysis confirmed that PsyCap significantly mediated the relationship between medication adherence and CRF (indirect effect = 0.357, 95% CI did not include zero), accounting for 55.68% of the total effect.</p><p><strong>Conclusion: </strong>PsyCap partially mediated the association between medication adherence and CRF. Interventions aimed at enhancing PsyCap may improve adherence and reduce CRF in breast cancer patients receiving long-term pharmacotherapy.</p>\",\"PeriodicalId\":12605,\"journal\":{\"name\":\"Frontiers in Psychiatry\",\"volume\":\"16 \",\"pages\":\"1615271\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259705/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fpsyt.2025.1615271\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpsyt.2025.1615271","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
摘要
背景：乳腺癌是世界范围内女性最常见的恶性肿瘤之一。尽管长期的药物治疗大大提高了生存率，但它往往伴随着心理负担，包括癌症相关疲劳（CRF）和对治疗的依从性降低。慢性肾功能衰竭是一种普遍的衰弱症状，对身体功能和情绪健康产生不利影响。心理资本（PsyCap）是一种包含自我效能、希望、乐观和弹性的结构，已被证明可以提高治疗参与度并促进心理健康。然而，其作为药物依从性和CRF之间潜在的心理中介的作用尚未得到彻底的研究。目的：探讨PsyCap在乳腺癌长期治疗患者服药依从性与CRF之间的中介作用。方法：采用方便抽样方法，选取2022年6月至2024年6月住院的100例乳腺癌患者。对90份有效问卷的数据进行分析。参与者完成PsyCap问卷（PCQ-24）、自我报告药物依从性评定量表（SR-MARS）和CRF量表（CFS）。使用Pearson相关分析来评估变量之间的关联。采用自举法对5000个样本进行中介分析。结果：两组患者的PsyCap、药物依从性和CRF平均得分分别为86.65±8.37、5.36±1.12和36.77±5.98。心理cap与药物依从性呈正相关（r = 0.994, p < 0.05），与CRF呈负相关（r = -0.992, p < 0.05）。服药依从性与CRF呈负相关（r = -0.994, p < 0.05）。中介分析证实PsyCap在药物依从性与CRF之间具有显著的中介作用（间接效应= 0.357,95% CI不含零），占总效应的55.68%。结论：PsyCap在药物依从性与CRF之间起部分介导作用。旨在增强PsyCap的干预措施可以改善接受长期药物治疗的乳腺癌患者的依从性并降低CRF。
Psychological capital mediates the relationship between medication adherence and cancer-related fatigue in breast cancer patients undergoing long-term treatment.
Background: Breast cancer is one of the most prevalent malignant tumors among women worldwide. Although long-term pharmacological treatment has substantially improved survival rates, it is often accompanied by psychological burdens, including cancer-related fatigue (CRF) and diminished adherence to therapy. CRF is a pervasive and debilitating symptom that adversely affects physical functioning and emotional well-being. Psychological capital (PsyCap), a construct encompassing self-efficacy, hope, optimism, and resilience, has been shown to enhance treatment engagement and promote mental health. However, its role as a potential psychological mediator between medication adherence and CRF is yet to be thoroughly investigated.
Objective: To investigate the mediating role of PsyCap in the relationship between medication adherence and CRF in patients with breast cancer undergoing long-term treatment.
Methods: A total of 100 breast cancer patients admitted between June 2022 and June 2024 were recruited using convenience sampling. Data from 90 valid responses were analyzed. Participants completed the PsyCap Questionnaire (PCQ-24), Self-Reported Medication Adherence Rating Scale (SR-MARS), and CRF Scale (CFS). Pearson's correlation analysis was used to assess associations among variables. A mediation analysis was conducted using the bootstrap method with 5,000 resamples.
Results: The mean scores for PsyCap, medication adherence, and CRF were 86.65 ± 8.37, 5.36 ± 1.12, and 36.77 ± 5.98, respectively. PsyCap was positively correlated with medication adherence (r = 0.994, p < 0.05) and negatively correlated with CRF (r = -0.992, p < 0.05). Medication adherence was also negatively correlated with CRF (r = -0.994, p < 0.05). Mediation analysis confirmed that PsyCap significantly mediated the relationship between medication adherence and CRF (indirect effect = 0.357, 95% CI did not include zero), accounting for 55.68% of the total effect.
Conclusion: PsyCap partially mediated the association between medication adherence and CRF. Interventions aimed at enhancing PsyCap may improve adherence and reduce CRF in breast cancer patients receiving long-term pharmacotherapy.
期刊介绍：
Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.
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