神经内分泌肿瘤中激素分泌的细胞机制：哪里出了问题？

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1527083

Laura Streit, Emeline Tanguy, Laurent Brunaud, Petra Tóth, Nicolas Vitale, Stéphane Ory, Stéphane Gasman

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引用次数: 0

摘要

神经内分泌肿瘤（NETs）是一类由激素释放细胞引起的异质性肿瘤。储存在囊泡中的激素通过钙调节的胞吐作用分泌，这一过程需要严格控制以避免激素水平不平衡。大多数NETs的一个关键特征是分泌通路功能失调，主要导致分泌过多，这往往会诱发临床并发症。在这篇综述中，我们关注激素分泌的细胞过程，并讨论导致各种NETs中激素分泌失调的潜在分子机制。特别关注的是在NETs中参与胞外通路的基因和蛋白质的表达水平改变。

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Cellular mechanisms of hormone secretion in neuroendocrine tumors: what goes wrong?

Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms arising from hormone-releasing cells. Secretion of hormones stored in vesicles occurs through calcium-regulated exocytosis, a process that needs to be tightly controlled to avoid unbalanced levels of hormones. A critical feature shared by most of the NETs is a dysfunctional secretory pathway mainly leading to hypersecretion, which often induces clinical complications. In this review, we focus on the cellular process of hormone exocytosis and discuss the potential molecular mechanisms leading to deregulated hormone secretion in various NETs. Particular attention is paid to expression level modifications for genes and proteins involved in the exocytic pathway in NETs.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.