Global Research Trends and Collaborative Networks in Cellular Therapy for Crohn's Disease: A Systematic Review and Bibliographic Analysis.

Introduction: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal system characterized by periods of remission and relapse. This study aims to provide a comprehensive bibliometric analysis of CD cellular therapy research over the past 30 years.

Methods: Data was accessed and downloaded from the Web of Science (WoS) database on June 18, 2024, using specific search terms related to CDs and cellular therapy, covering the years 1992-2023. The search was limited to articles and review articles in English. The data was analyzed using R Studio Bibliometric to evaluate metrics such as global and local citations, source journals, and fractionalized author contributions.

Results: The analysis identified 559 documents from 258 sources, with an annual growth rate of 13.45%. The dataset included 309 original research articles and 234 review articles, contributed by 3,181 authors. A significant publication increase was observed from 2009 onward, peaking in 2019. The mean total citations per year showed notable fluctuations, with peaks in 2000 and 2007. The Cleveland Clinic Foundation, Sun Yat-Sen University, and Mayo Clinic were prominent institutions contributing to the research. The USA led publication output and citations, followed by Spain, China, Italy, and Canada.

Conclusion: The management of CD has evolved significantly with advancements in cellular therapy and therapeutic strategies. Despite the growth in research and available treatment options, there remains a lack of broad consensus in clinical practice. This bibliometric analysis highlights the progress in cellular therapy for CD.