Junshen Xiao, Xu Cheng, Dou Huang, Shichao Wei, Zhaoyang Hu
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Functions of the KCNE Gene Family in Ion Channels.
The KCNE gene family is crucial for physiological and pathological processes in the body and encodes small transmembrane proteins that function as auxiliary subunits to regulate voltage-gated potassium channels (Kv channels). This family includes five members, KCNE1, KCNE2, KCNE3, KCNE4, and KCNE5, whose encoded proteins are referred to as MinK and MinK-related peptides (MiRPs), which influence the properties and localization of Kv. When KCNE is coexpressed with Kv, it can alter the conductance, gating kinetics, and pharmacology of the channel. Therefore, these genes are particularly important for action potentials in excitable cells, and mutations in these genes can lead to significant diseases. In this paper, we review the functional roles of KCNE genes and their effects on Kv α subunits to further understand the regulatory effects of KCNE in modulating ion channels.
期刊介绍：
Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses.
Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication.
Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses.
Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods.
Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.
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