尿金属和酚混合物,氧化应激和心率变异性:关联和中介分析。

IF 6.1 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ecotoxicology and Environmental Safety Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI:10.1016/j.ecoenv.2025.118669
Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang
{"title":"尿金属和酚混合物,氧化应激和心率变异性:关联和中介分析。","authors":"Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang","doi":"10.1016/j.ecoenv.2025.118669","DOIUrl":null,"url":null,"abstract":"<p><p>Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118669"},"PeriodicalIF":6.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary metals and phenols mixtures, oxidative stress, and heart rate variability: Association and mediation analyses.\",\"authors\":\"Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang\",\"doi\":\"10.1016/j.ecoenv.2025.118669\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.</p>\",\"PeriodicalId\":303,\"journal\":{\"name\":\"Ecotoxicology and Environmental Safety\",\"volume\":\"302 \",\"pages\":\"118669\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ecotoxicology and Environmental Safety\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ecoenv.2025.118669\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecotoxicology and Environmental Safety","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1016/j.ecoenv.2025.118669","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

很少有研究调查了金属和酚类物质共同暴露对心率变异性(HRV)的影响,其潜在机制尚不清楚。我们的目的是通过3次重复访问,研究武汉118名成年人中金属和酚类物质与HRV的个体和联合关联以及氧化应激的介导作用。检测尿样中23种金属、6种酚类物质和3种氧化应激生物标志物。使用线性混合效应模型(LMEs)、加权分位数和(WQS)回归、自适应最小绝对收缩和选择算子(LASSO)和中介分析来估计相关性。WQS回归表明,金属和酚类混合物与正态间隔标准差(SDNN)呈总体负相关,与低频/高频比(LF/HF)呈正相关。对于SDNN,采用自适应LASSO选择尿铊(Tl)和对羟基苯甲酸丙酯(PrP), LF/HF选择尿Tl。多因素调整后,我们发现尿Tl和PrP每增加一倍,分别与SDNN下降3.54 %(95 % CI: -6.01 %,-1.01 %)和1.20 %(95 % CI: -2.05 %,-0.33 %)相关。尿Tl和PrP与SDNN的负相关关系由尿8-异前列腺素- f2 α (8-isoPGF2])和8-羟基-2'-脱氧鸟苷(8-OHdG)介导,其介导比例分别为15.83 %和8.36 %。我们的研究结果表明,环境暴露于Tl和PrP与HRV降低有关,并且这种关联部分是由氧化应激介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Urinary metals and phenols mixtures, oxidative stress, and heart rate variability: Association and mediation analyses.

Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信