Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang
{"title":"尿金属和酚混合物,氧化应激和心率变异性:关联和中介分析。","authors":"Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang","doi":"10.1016/j.ecoenv.2025.118669","DOIUrl":null,"url":null,"abstract":"<p><p>Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.</p>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"302 ","pages":"118669"},"PeriodicalIF":6.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary metals and phenols mixtures, oxidative stress, and heart rate variability: Association and mediation analyses.\",\"authors\":\"Min Xiang, Huihua Yang, Ziqian Zhang, Wenting Guo, Miao Liu, Chong Liu, Suli Huang, Xiaomin Zhang, Liangle Yang\",\"doi\":\"10.1016/j.ecoenv.2025.118669\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.</p>\",\"PeriodicalId\":303,\"journal\":{\"name\":\"Ecotoxicology and Environmental Safety\",\"volume\":\"302 \",\"pages\":\"118669\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ecotoxicology and Environmental Safety\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ecoenv.2025.118669\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecotoxicology and Environmental Safety","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1016/j.ecoenv.2025.118669","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Urinary metals and phenols mixtures, oxidative stress, and heart rate variability: Association and mediation analyses.
Few studies have examined the effects of co-exposure to metals and phenols on heart rate variability (HRV), and the underlying mechanisms are unknown. We aim to investigate individual and joint associations of metals and phenols with HRV and the mediating role of oxidative stress among 118 adults in Wuhan with 3 repeated visits. Urine samples of 23 metals, 6 phenols and 3 oxidative stress biomarkers were measured. The associations were estimated using linear mixed-effect models (LMEs), weighted quantile sum (WQS) regression, adaptive Least Absolute Shrinkage and Selection Operator (LASSO) and mediation analyses. WQS regression revealed that the mixture of metals and phenols had an overall inverse association with standard deviation of normal-to-normal intervals (SDNN) and a positive relationship with low-frequency/high-frequency ratio (LF/HF). For SDNN, urinary thallium (Tl) and propyl paraben (PrP) were selected by adaptive LASSO, and urinary Tl was selected for LF/HF. After multivariate adjustments, we found that per doubling of urinary Tl and PrP was associated with a 3.54 % (95 % CI: -6.01 %, -1.01 %) and 1.20 % (95 % CI: -2.05 %, -0.33 %) decrease in SDNN, respectively. Additionally, the inverse relationships of urinary Tl and PrP with SDNN were mediated by urinary 8-iso-prostaglandin-F2α (8-isoPGF2ɑ) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), with the mediated proportions of 15.83 % and 8.36 %, respectively. Our findings suggest that environmental exposure to Tl and PrP was associated with decreased HRV, and the association was partly mediated by oxidative stress.
期刊介绍:
Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.