硒取代BOIMPY增强光动力疗法。

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-06-20 eCollection Date: 2025-07-10 DOI:10.1021/acsmedchemlett.5c00174

Sorachat Tharamak, Bongkot Ouengwanarat, Tunyawat Khrootkaew, Prapassara Muangsopa, Kantapat Chansaenpak, Kenika Khotchasanthong, Kittipong Chainok, Kevin Burgess, Anyanee Kamkaew

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引用次数: 0

摘要

硒取代的双（二氟化硼）-8-咪唑-二吡啶（BOIMPY）衍生物比扭曲的BOIMPY衍生物表现出更好的光物理特性，例如更大的Stokes位移，同时影响辐射松弛和系统间交叉，使其适合成像引导光动力治疗（PDT）。其中一种在近红外光激活下表现出对癌细胞的I型和II型PDT的改善。其在纳摩尔范围内的显著光毒性和最小的暗毒性证明了其作为癌症治疗的靶向PDT剂的潜力。

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Selenium-Substituted BOIMPY for Enhanced Photodynamic Therapy.

Seleno-substituted bis-(boron difluoride)-8-imidazo-dipyrro-methene (BOIMPY) derivatives displayed improved photophysical features over twisted-BOIMPY, such as greater Stokes shifts, while compromising radiative relaxation and intersystem crossing, making them suitable for imaging-guided photodynamic therapy (PDT). One exhibited improved Type I and Type II PDT against cancer cells when activated by near-infrared light. Its potential as a targeted PDT agent for cancer treatment is demonstrated by its remarkable phototoxicity in the nanomolar range and minimal dark toxicity.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.