新型（1H -吡唑-4-氨基）嘧啶衍生物作为Wee1抑制剂用于治疗癌症。

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-06-18 eCollection Date: 2025-07-10 DOI:10.1021/acsmedchemlett.5c00343

Steven H Liang

引用次数: 0

摘要

本专利描述了一系列新的（1h -吡唑-4-氨基）-嘧啶衍生物、它们的盐类或互变异构体、组合物和制备方法。这些化合物被设计为选择性Wee1抑制剂，用于治疗癌症，包括髓母细胞瘤和弥漫性内在脑桥胶质瘤（DlPG）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Novel (1H‑Pyrazol-4-ylamino)pyrimidine Derivatives as Wee1 Inhibitors for Treatment of Cancer.

This patent describes a series of novel (1H-pyrazol-4-ylamino)-pyrimidine derivatives, their salts or tautomer, and compositions and methods of preparation. These compounds are designed as selective Wee1 inhibitors for the treatment of cancer, including medulloblastoma and diffuse intrinsic pontine glioma (DlPG).

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.