阿斯利康通过学术-工业合作推进同位素标记技术。

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-06-20 eCollection Date: 2025-07-10 DOI:10.1021/acsmedchemlett.5c00338

Ryan A Bragg, Jonas Bergare, Markus Artelsmair, William J Kerr, Troels Skrydstrup, Charles S Elmore

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引用次数: 0

摘要

学术-工业合作在为阿斯利康同位素化学团队开发新的合成方法方面发挥了重要作用。在这个观点中，我们提出了两个合作的结果，并说明了通过这些伙伴关系开发的创新方法如何在阿斯利康项目中得到有效应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advancing Isotope Labeling Technologies at AstraZeneca through Academic-Industrial Collaboration.

Academic-Industrial collaborations have played an important role in developing new synthetic methodologies for the isotope chemistry team at AstraZeneca. In this viewpoint, we present the outcome of two collaborations and illustrate how the innovative methodologies developed through these partnerships have been effectively applied within an AstraZeneca project.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.