Mette Peters Michaelsen, Laura Cæcilie Nielsen, Michelle Poulsen, Regitze Gyldenholm Skals, Bettina Troest, Janne Gasseholm Bentzen, Jimmi Elers, Anette Vestergaard Gabrielsen, Marie Louise Grøndahl, Betina Boel Povlsen, Mikael Tang-Pedersen, Ulrik Schiøler Kesmodel
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Further, ever use of LNG-IUS was categorised into 0–3 years, > 3–6 years, > 6–9 years and > 9 years. Mixed effect logistic regression adjusted for age, BMI, smoking, educational level, total FSH dose and fertility clinic was used.</p>\n </section>\n \n <section>\n \n <h3> Main Outcome Measure (s)</h3>\n \n <p>EMT (< 7 mm ≥ 7 mm).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Statistically significantly higher odds of EMT ≥ 7 mm were found for OCPs [odds ratio (OR) 3.53 (95% confidence interval (95% CI) 1.29–9.65)], POPs [OR 6.43, (95% CI 1.45–28.63)] and no/other contraception [OR 6.67, (95% CI 2.37–18.74]) relative to LNG-IUS in IVF/ICSI cycles. Further, all duration categories of ever use of LNG-IUS were associated with statistically significantly lower odds of obtaining an EMT ≥ 7 mm compared to no/other contraception.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In this study, previous use of LNG-IUS was associated with decreased endometrial growth in women undergoing IVF/ICSI.</p>\n </section>\n </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1681-1688"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18295","citationCount":"0","resultStr":"{\"title\":\"Hormonal Contraception and Endometrial Thickness in IVF/ICSI Cycles: A Multicentre Historical Cohort Study\",\"authors\":\"Mette Peters Michaelsen, Laura Cæcilie Nielsen, Michelle Poulsen, Regitze Gyldenholm Skals, Bettina Troest, Janne Gasseholm Bentzen, Jimmi Elers, Anette Vestergaard Gabrielsen, Marie Louise Grøndahl, Betina Boel Povlsen, Mikael Tang-Pedersen, Ulrik Schiøler Kesmodel\",\"doi\":\"10.1111/1471-0528.18295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To study the association between previous use of levonorgestrel intrauterine system (LNG-IUS) and endometrial thickness (EMT) in women undergoing in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Design</h3>\\n \\n <p>Multicentre historical cohort study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Setting</h3>\\n \\n <p>Eight Danish public and private fertility clinics.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Population</h3>\\n \\n <p>12786 women aged 18–46 years contributing with an EMT measurement from 22 464 different IVF/ICSI treatment cycles between 2000 and 2021.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Exposure was previous use of LNG-IUS, combined oral contraceptive pills (OCPs), progeste-only pills (POPs), no/other contraception or combined, cumulated use of contraception when more contraceptives had been used during the inclusion period. 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引用次数: 0
摘要
目的探讨体外受精(IVF)/胞浆内单精子注射（ICSI）周期妇女既往使用左炔诺孕酮宫内系统（LNG-IUS）与子宫内膜厚度（EMT）的关系。设计多中心历史队列研究。八家丹麦公立和私立生育诊所。12786名年龄在18-46岁之间的女性在2000年至2021年间进行了22464个不同的IVF/ICSI治疗周期的EMT测量。方法观察患者既往使用LNG-IUS、联合口服避孕药（ocp）、仅孕激素避孕药（POPs）、无/其他避孕措施或在纳入期内使用较多避孕措施时的联合、累计使用情况。此外，LNG-IUS的使用年限分为0-3年、3-6年、6-9年和9年。采用混合效应logistic回归校正年龄、BMI、吸烟、文化程度、FSH总剂量和生育诊所。主要结局指标：EMT （< 7 mm≥7 mm）。结果在IVF/ICSI周期中，与LNG-IUS相比，ocp[比值比（OR） 3.53(95%可信区间（95% CI） 1.29-9.65)]、POPs [OR 6.43, (95% CI 1.45-28.63)]和无/其他避孕方法[OR 6.67, （95% CI 2.37-18.74]）的EMT≥7 mm的几率更高，具有统计学意义。此外，与没有/其他避孕方法相比，所有持续时间类别的曾经使用过LNG-IUS的患者获得≥7 mm EMT的几率都有统计学意义上的显著降低。结论：在本研究中，先前使用LNG-IUS与接受IVF/ICSI的女性子宫内膜生长减少有关。
Hormonal Contraception and Endometrial Thickness in IVF/ICSI Cycles: A Multicentre Historical Cohort Study
Objective
To study the association between previous use of levonorgestrel intrauterine system (LNG-IUS) and endometrial thickness (EMT) in women undergoing in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Design
Multicentre historical cohort study.
Setting
Eight Danish public and private fertility clinics.
Population
12786 women aged 18–46 years contributing with an EMT measurement from 22 464 different IVF/ICSI treatment cycles between 2000 and 2021.
Methods
Exposure was previous use of LNG-IUS, combined oral contraceptive pills (OCPs), progeste-only pills (POPs), no/other contraception or combined, cumulated use of contraception when more contraceptives had been used during the inclusion period. Further, ever use of LNG-IUS was categorised into 0–3 years, > 3–6 years, > 6–9 years and > 9 years. Mixed effect logistic regression adjusted for age, BMI, smoking, educational level, total FSH dose and fertility clinic was used.
Main Outcome Measure (s)
EMT (< 7 mm ≥ 7 mm).
Results
Statistically significantly higher odds of EMT ≥ 7 mm were found for OCPs [odds ratio (OR) 3.53 (95% confidence interval (95% CI) 1.29–9.65)], POPs [OR 6.43, (95% CI 1.45–28.63)] and no/other contraception [OR 6.67, (95% CI 2.37–18.74]) relative to LNG-IUS in IVF/ICSI cycles. Further, all duration categories of ever use of LNG-IUS were associated with statistically significantly lower odds of obtaining an EMT ≥ 7 mm compared to no/other contraception.
Conclusions
In this study, previous use of LNG-IUS was associated with decreased endometrial growth in women undergoing IVF/ICSI.
期刊介绍：
BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.
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