瑞士光源和瑞士自由电子激光器下大分子晶体学光束线的演变。

IF 3 3区物理与天体物理

Journal of Synchrotron Radiation Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI:10.1107/S1600577525005016

Meitian Wang

{"title":"瑞士光源和瑞士自由电子激光器下大分子晶体学光束线的演变。","authors":"Meitian Wang","doi":"10.1107/S1600577525005016","DOIUrl":null,"url":null,"abstract":"This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.","PeriodicalId":48729,"journal":{"name":"Journal of Synchrotron Radiation","volume":" ","pages":"1162-1183"},"PeriodicalIF":3.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416430/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.\",\"authors\":\"Meitian Wang\",\"doi\":\"10.1107/S1600577525005016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.\",\"PeriodicalId\":48729,\"journal\":{\"name\":\"Journal of Synchrotron Radiation\",\"volume\":\" \",\"pages\":\"1162-1183\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416430/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Synchrotron Radiation\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1107/S1600577525005016\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Synchrotron Radiation","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1107/S1600577525005016","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

本文综述了近二十年来瑞士光源（SLS）下三种大分子晶体学（MX）光束线的发展和演变。我们讨论了x射线光学、探测器、测角仪、样品交换器和MX方法的关键进展，强调了它们对高通量和高分辨率结构生物学的影响。我们的贡献是在基于同步加速器的MX的全球努力的更广泛背景下提出的。展望未来，我们将探索SLS 2.0支持的未来实验以及瑞士自由电子实验室的新机遇，以提高实验能力并推动科学发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.

This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Synchrotron Radiation INSTRUMENTS & INSTRUMENTATIONOPTICS&-OPTICS

CiteScore

5.60

自引率

12.00%

发文量

289

审稿时长

1 months

期刊介绍： Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally. Synchrotron radiation plays a leading role in pure science and in emerging technologies. The Journal of Synchrotron Radiation provides comprehensive coverage of the entire field of synchrotron radiation and free-electron laser research including instrumentation, theory, computing and scientific applications in areas such as biology, nanoscience and materials science. Rapid publication ensures an up-to-date information resource for scientists and engineers in the field.