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引用次数: 0
摘要
本综述系统地探讨了天然生物活性物质在牙组织生物矿化中的作用。通过对PubMed、Web of Science和Scopus检索到的同行评议文献（2000-2024）进行综合分析，使用关键词包括“天然药物”、“生物矿化”和“牙齿修复”，我们评估了三个关键方面：(1)当前修复材料（复合树脂、粘合剂）的局限性；(2)天然化合物（胶原蛋白保护、矿物质沉积、脱矿抑制）的作用机制；(3)临床翻译的挑战。我们的分析表明，植物衍生的类黄酮、多酚和生物活性肽在解决毒性问题的同时，特别有希望增强再矿化。该综述最后提出了开发下一代生物活性修复材料的研究框架，强调了长期稳定性和标准化方案方面的知识差距。
Biomineralization of dental tissues with natural drugs: a comprehensive review.
This narrative review systematically examines the emerging role of natural bioactive substances in dental tissue biomineralization. Through comprehensive analysis of peer-reviewed literature (2000-2024) identified via PubMed, Web of Science, and Scopus using keywords including 'natural drugs,' 'biomineralization,' and 'dental restoration,' we evaluate three key aspects: (1) the limitations of current restorative materials (composite resins, adhesives); (2) the mechanisms of natural compounds (collagen protection, mineral deposition, demineralization inhibition); and (3) clinical translation challenges. Our analysis reveals that plant-derived flavonoids, polyphenols, and bioactive peptides show particular promise for enhancing remineralization while addressing toxicity concerns. The review concludes by proposing a research framework for developing next-generation bioactive restorative materials, highlighting knowledge gaps in long-term stability and standardized protocols.
期刊介绍：
Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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