[基于基因组和表观基因组生物标志物的儿童肥胖研究进展]。

Q3 Medicine

中华预防医学杂志 Pub Date : 2025-07-06 DOI:10.3760/cma.j.cn112150-20240729-00606

Z W Xia, H Zhao, T T Liu, Y Li, J S Huo, X Guo

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引用次数: 0

摘要

肥胖是一种复杂的、可遗传的疾病，由遗传、表观遗传、宏基因组和环境因素相互作用形成。然而，遗传变异和表观遗传调控在肥胖发病机制中的作用机制尚未完全阐明。分子分析技术的进步已经能够识别与儿童肥胖表型相关的许多生物标志物。这些发现有助于理解肥胖的病因及其与慢性疾病的联系。本文综述了影响儿童肥胖易感性的基因组和表观基因组生物标志物的研究现状，促进了我们对病因异质性和干预策略的理解，并为基于表观遗传机制的精确预防提供了概念框架。

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[Research progress of childhood obesity based on genomic and epigenomic biomarkers].

Obesity represents a complex, heritable condition shaped by interactions among genetic, epigenetic, metagenomic, and environmental factors. Nevertheless, the mechanistic contributions of genetic variation and epigenetic regulation to obesity pathogenesis remain incompletely elucidated. Advances in molecular profiling technologies have enabled the identification of numerous biomarkers associated with childhood obesity phenotypes. These discoveries facilitate understanding of obesity etiology and its links to chronic diseases. This review synthesizes current research on genomic and epigenomic biomarkers influencing childhood obesity susceptibility, advances our comprehension of etiological heterogeneity and intervention strategies, and offers conceptual frameworks for precision prevention based on epigenetic mechanisms.

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来源期刊

中华预防医学杂志 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

12678

期刊介绍： Chinese Journal of Preventive Medicine (CJPM), the successor to Chinese Health Journal , was initiated on October 1, 1953. In 1960, it was amalgamated with the Chinese Medical Journal and the Journal of Medical History and Health Care , and thereafter, was renamed as People’s Care . On November 25, 1978, the publication was denominated as Chinese Journal of Preventive Medicine . The contents of CJPM deal with a wide range of disciplines and technologies including epidemiology, environmental health, nutrition and food hygiene, occupational health, hygiene for children and adolescents, radiological health, toxicology, biostatistics, social medicine, pathogenic and epidemiological research in malignant tumor, surveillance and immunization.