[单次高脂餐前后代谢相关脂肪肝患者血清NLRP3水平与血脂的相关性]。

Q3 Medicine

中华肝脏病杂志 Pub Date : 2025-06-20 DOI:10.3760/cma.j.cn501113-20241015-00542

K J Zheng, Q Q Liu, Y H Rong, X J Wang, L P Hou, W Gu, G Y Song

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Multiple linear regression analysis was used to evaluate the influencing factors of area under the operating curve (AUCNLRP3) of serum NLRP3 subjects. Logistic regression analysis was used to evaluate the correlation between serum AUCNLRP3 and the risk of MAFLD. Results: The levels of TC, TG, LDL-C, and NLRP3 were significantly higher in the fasting group than the CON group at 2 h, 4 h, and 6 h after a meal [TC (mmol/L), fasting: (5.29±1.01) vs. (4.28±0.62), 2 h: (5.24±0.98) vs. (4.25±0.62), 4 h: (5.38±1.04) vs. (4.26±0.63), 6 h: (5.54±1.07) vs. (4.41±0.65); TG (mmol/L), fasting: (2.67±0.96) vs. (0.92±0.33), 2 h: (3.91±1.35) vs. (1.69±0.59), 4 h: (5.09±1.7) vs. (1.91±0.93), 6 h: (5.36±2.27) vs. (1.75±1.03); LDL-C (mmol/L), fasting: (3.47±0.74) vs. (2.65±0.49), 2 h: (3.36±0.71) vs. (2.58±0.49), 4 h: (3.30±0.71) vs. (2.55±0.47), 6 h: (3.36±0.74) vs. (2.63±0.48); NLRP3 (ng/L), fasting: (84.63±12.96) vs. (56.71±11.37), 2 h: (106.06±17.76) vs. (69.12±14.92), 4 h: (89.78±15.98) vs. (57.74±12.34), 6 h: (80.03±13.61) vs. (54.06±10.35); P<0.001], while the HDL-C level was significantly lower than the CON group [HDL-C (mmol/L), fasting: (1.14±0.24) vs. (1.33±0.29), 2 h: (1.14±0.24) vs. (1.33±0.29), 4 h: (1.09±0.24) vs. (1.27±0.28), and 6 h: (1.05±0.26) vs. (1.29±0.30); P<0.001]. Serum AUCNLRP3 was significantly correlated with AUCTG and AUCLDL-C (AUCTG: B=7.391, 95%CI:5.662-9.12; AUCLDL-C: B=6.559, 95%CI:3.052-10.065; P<0.001) after adjusting for confounding factors, and it was identified as an independent influencing factor for MAFLD (OR=1.039, 95%CI:1.007-1.071;P=0.015). 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Results: The levels of TC, TG, LDL-C, and NLRP3 were significantly higher in the fasting group than the CON group at 2 h, 4 h, and 6 h after a meal [TC (mmol/L), fasting: (5.29±1.01) vs. (4.28±0.62), 2 h: (5.24±0.98) vs. (4.25±0.62), 4 h: (5.38±1.04) vs. (4.26±0.63), 6 h: (5.54±1.07) vs. (4.41±0.65); TG (mmol/L), fasting: (2.67±0.96) vs. (0.92±0.33), 2 h: (3.91±1.35) vs. (1.69±0.59), 4 h: (5.09±1.7) vs. (1.91±0.93), 6 h: (5.36±2.27) vs. (1.75±1.03); LDL-C (mmol/L), fasting: (3.47±0.74) vs. (2.65±0.49), 2 h: (3.36±0.71) vs. (2.58±0.49), 4 h: (3.30±0.71) vs. (2.55±0.47), 6 h: (3.36±0.74) vs. (2.63±0.48); NLRP3 (ng/L), fasting: (84.63±12.96) vs. (56.71±11.37), 2 h: (106.06±17.76) vs. (69.12±14.92), 4 h: (89.78±15.98) vs. (57.74±12.34), 6 h: (80.03±13.61) vs. (54.06±10.35); P<0.001], while the HDL-C level was significantly lower than the CON group [HDL-C (mmol/L), fasting: (1.14±0.24) vs. (1.33±0.29), 2 h: (1.14±0.24) vs. (1.33±0.29), 4 h: (1.09±0.24) vs. (1.27±0.28), and 6 h: (1.05±0.26) vs. (1.29±0.30); P<0.001]. 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引用次数: 0

摘要

目的：探讨单次高脂餐前后代谢相关脂肪肝（MAFLD）患者血清nod样受体蛋白3 （NLRP3）水平与血脂的相关性。方法：采用回顾性队列研究。纳入2019年2月至2019年12月在河北省人民医院招募的MAFLD患者63例（MAFLD组）和健康受试者54例（CON组）。比较两组的基线数据，并进行单次高脂餐试验。在禁食和高脂餐后2小时、4小时和6小时测量总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和NLRP3水平。采用多元线性回归分析评价血清NLRP3受试者工作曲线下面积（AUCNLRP3）的影响因素。采用Logistic回归分析评价血清AUCNLRP3水平与MAFLD发病风险的相关性。结果：空腹组在餐后2 h、4 h、6 h的TC、TG、LDL-C、NLRP3水平均显著高于对照组[TC (mmol/L)，空腹组：（5.29±1.01）比（4.28±0.62），空腹组：（5.24±0.98）比（4.25±0.62），空腹组：（5.38±1.04）比（4.26±0.63），空腹组：（5.54±1.07）比（4.41±0.65）；TG(更易/ L),禁食:(2.67±0.96)和(0.92±0.33),2 h:(3.91±1.35)和(1.69±0.59),4 h:(5.09±1.7)和(1.91±0.93),6 h:(5.36±2.27)和(1.75±1.03);低密度(更易/ L),禁食:(3.47±0.74)和(2.65±0.49),2 h:(3.36±0.71)和(2.58±0.49),4 h:(3.30±0.71)和(2.55±0.47),6 h:(3.36±0.74)和(2.63±0.48);NLRP3 (ng / L),禁食:(84.63±12.96)和(56.71±11.37),2 h:(106.06±17.76)和(69.12±14.92),4 h:(89.78±15.98)和(57.74±12.34),6 h:(80.03±13.61)和(54.06±10.35);pv。(1.33±0.29),2 h:(1.14±0.24)和(1.33±0.29),4 h:(1.09±0.24)和(1.27±0.28),和6 h:(1.05±0.26)和(1.29±0.30);P0.001]。血清AUCNLRP3与AUCTG、AUCLDL-C显著相关(AUCTG: B=7.391, 95%CI:5.662-9.12；aucld - c: b =6.559, 95%ci:3.052-10.065；= 1.039, 95% ci: 1.007—-1.071;P = 0.015)。结论：单次高脂餐前后血清NLRP3水平与TG和LDL-C水平升高显著相关，并可能影响MAFLD的进展。

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[Correlation between serum NLRP3 levels and serum lipids in metabolic-associated fatty liver disease before and after a single high-fat meal].

Objective: To investigate the correlation between serum NOD-like receptor protein 3 (NLRP3) levels and serum lipids in metabolic-associated fatty liver disease (MAFLD) before and after a single high-fat meal. Methods: A retrospective cohort study was conducted. Sixty-three MAFLD patients (MAFLD group) and fifty-four healthy subjects (CON group) recruited from February 2019 to December 2019 at Hebei Provincial People's Hospital were included. The baseline data were compared between the two groups, and a single high-fat meal trial was conducted. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and NLRP3 were measured at 2 h, 4 h, and 6 h after fasting and a high-fat meal. Multiple linear regression analysis was used to evaluate the influencing factors of area under the operating curve (AUC_NLRP3) of serum NLRP3 subjects. Logistic regression analysis was used to evaluate the correlation between serum AUC_NLRP3 and the risk of MAFLD. Results: The levels of TC, TG, LDL-C, and NLRP3 were significantly higher in the fasting group than the CON group at 2 h, 4 h, and 6 h after a meal [TC (mmol/L), fasting: (5.29±1.01) vs. (4.28±0.62), 2 h: (5.24±0.98) vs. (4.25±0.62), 4 h: (5.38±1.04) vs. (4.26±0.63), 6 h: (5.54±1.07) vs. (4.41±0.65); TG (mmol/L), fasting: (2.67±0.96) vs. (0.92±0.33), 2 h: (3.91±1.35) vs. (1.69±0.59), 4 h: (5.09±1.7) vs. (1.91±0.93), 6 h: (5.36±2.27) vs. (1.75±1.03); LDL-C (mmol/L), fasting: (3.47±0.74) vs. (2.65±0.49), 2 h: (3.36±0.71) vs. (2.58±0.49), 4 h: (3.30±0.71) vs. (2.55±0.47), 6 h: (3.36±0.74) vs. (2.63±0.48); NLRP3 (ng/L), fasting: (84.63±12.96) vs. (56.71±11.37), 2 h: (106.06±17.76) vs. (69.12±14.92), 4 h: (89.78±15.98) vs. (57.74±12.34), 6 h: (80.03±13.61) vs. (54.06±10.35); P<0.001], while the HDL-C level was significantly lower than the CON group [HDL-C (mmol/L), fasting: (1.14±0.24) vs. (1.33±0.29), 2 h: (1.14±0.24) vs. (1.33±0.29), 4 h: (1.09±0.24) vs. (1.27±0.28), and 6 h: (1.05±0.26) vs. (1.29±0.30); P<0.001]. Serum AUC_NLRP3 was significantly correlated with AUC_TG and AUC_LDL-C (AUC_TG: B=7.391, 95%CI:5.662-9.12; AUC_LDL-C: B=6.559, 95%CI:3.052-10.065; P<0.001) after adjusting for confounding factors, and it was identified as an independent influencing factor for MAFLD (OR=1.039, 95%CI:1.007-1.071;P=0.015). Conclusion: The serum NLRP3 levels before and after a single high-fat meal are significantly associated with elevated TG and LDL-C levels, and may influence the progression of MAFLD.

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中华肝脏病杂志 Medicine-Medicine (all)

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1.20

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0.00%

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7574

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