{"title":"中国西南高原男性人乳头瘤病毒分子流行病学趋势：11年回顾性分析（2014-2024）","authors":"Jian-Peng Hu, Jun-Ling Wang, Yun Li, Mei Yang, Jing Li, Hong-Ying Li, Na Qiao, Chao-Fu Yue, Hong-Xia Liu, Xiu-Ping Li, Jin-Si Yang, Qian Xiong, Zhe-Wei Fang, Jian-Dong Zhang, Ting Ji, Zong-Sheng Wu, Rui Zhu, Yin-Yu Zhou, Fan Zhang, Shu-Min Li, Hong-Na Li, Chun-Ju Yang, Zheng-Fu Zhang, Fei He, Yan-Liang Zhang, Yong Sun, Hong-Wei Li","doi":"10.1186/s12985-025-02861-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Persistent high-risk human papillomavirus (HR-HPV) infection may increase the risk of malignancies in males, including penile, rectal, anal, prostate, bladder, and oropharyngeal cancers. However, few studies focused on the epidemiology of human papillomavirus (HPV) in male patients. This study aims to retrospectively investigate the trends of HPV molecular epidemiology in males residing in the plateau region of Southwest China from 2014 to 2024.</p><p><strong>Methods: </strong>This retrospective study investigated the trends of HPV molecular epidemiology in 3580 males residing in the plateau region of southwest China from 2014 to 2024. Samples were collected for DNA extraction, and detection of 27 HPV genotypes by Luminex xMAP technology.</p><p><strong>Results: </strong>HPV prevalence fluctuated between 43.17% and 56.02% over the 11 years, with an average prevalence of 50.28% (1800/3580, 95% CI: 48.64%-51.92%). Among infected individuals, LR-HPV alone, HR-HPV alone, and mixed infection accounted for 71.00%, 9.83%, and 19.17%, respectively. Single, dual, triple, quadruple, and other multiple infections accounted for 73.22%, 18.28%, 5.33%, 2.22%, and 0.95%, respectively. HPV prevalence varied by clinical diagnosis: the highest in warts (76.99%, 1114/1447), followed by neoplasms (67.15%, 92/137), other diagnoses (39.10%, 364/931), rash (30.17%, 73/242), urinary inflammation (24.23%, 47/194), and asymptomatic individuals (17.49%, 110/629). Age-specific HPV prevalence exhibited a U-shaped bimodal pattern. The top five HR-HPV genotypes were HPV16 (2.35%), HPV59 (2.18%), HPV52 (1.68%), HPV56 (1.54%), and HPV39 (1.48%), while the top three LR-HPV genotypes were HPV6 (26.45%), HPV11 (16.82%), and HPV43 (1.98%). The coverage rates of the currently available bivalent, quadrivalent, and nonavalent HPV vaccines were 5.18%, 66.84%, and 73.17%, respectively. However, these vaccines do not cover HPV51, HPV39, HPV59, HPV56, HPV53, HPV43, and HPV61, which are highly prevalent genotypes in the Chinese population.</p><p><strong>Conclusion: </strong>These findings highlight the urgent need for developing and promoting HPV vaccines tailored to the Chinese population and accelerating HPV vaccination programs among adolescents. Integrating male HPV vaccination into the national immunization program could significantly reduce the burden of HPV-related infections and diseases.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"238"},"PeriodicalIF":4.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257770/pdf/","citationCount":"0","resultStr":"{\"title\":\"Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014-2024).\",\"authors\":\"Jian-Peng Hu, Jun-Ling Wang, Yun Li, Mei Yang, Jing Li, Hong-Ying Li, Na Qiao, Chao-Fu Yue, Hong-Xia Liu, Xiu-Ping Li, Jin-Si Yang, Qian Xiong, Zhe-Wei Fang, Jian-Dong Zhang, Ting Ji, Zong-Sheng Wu, Rui Zhu, Yin-Yu Zhou, Fan Zhang, Shu-Min Li, Hong-Na Li, Chun-Ju Yang, Zheng-Fu Zhang, Fei He, Yan-Liang Zhang, Yong Sun, Hong-Wei Li\",\"doi\":\"10.1186/s12985-025-02861-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Persistent high-risk human papillomavirus (HR-HPV) infection may increase the risk of malignancies in males, including penile, rectal, anal, prostate, bladder, and oropharyngeal cancers. However, few studies focused on the epidemiology of human papillomavirus (HPV) in male patients. This study aims to retrospectively investigate the trends of HPV molecular epidemiology in males residing in the plateau region of Southwest China from 2014 to 2024.</p><p><strong>Methods: </strong>This retrospective study investigated the trends of HPV molecular epidemiology in 3580 males residing in the plateau region of southwest China from 2014 to 2024. Samples were collected for DNA extraction, and detection of 27 HPV genotypes by Luminex xMAP technology.</p><p><strong>Results: </strong>HPV prevalence fluctuated between 43.17% and 56.02% over the 11 years, with an average prevalence of 50.28% (1800/3580, 95% CI: 48.64%-51.92%). Among infected individuals, LR-HPV alone, HR-HPV alone, and mixed infection accounted for 71.00%, 9.83%, and 19.17%, respectively. Single, dual, triple, quadruple, and other multiple infections accounted for 73.22%, 18.28%, 5.33%, 2.22%, and 0.95%, respectively. HPV prevalence varied by clinical diagnosis: the highest in warts (76.99%, 1114/1447), followed by neoplasms (67.15%, 92/137), other diagnoses (39.10%, 364/931), rash (30.17%, 73/242), urinary inflammation (24.23%, 47/194), and asymptomatic individuals (17.49%, 110/629). Age-specific HPV prevalence exhibited a U-shaped bimodal pattern. The top five HR-HPV genotypes were HPV16 (2.35%), HPV59 (2.18%), HPV52 (1.68%), HPV56 (1.54%), and HPV39 (1.48%), while the top three LR-HPV genotypes were HPV6 (26.45%), HPV11 (16.82%), and HPV43 (1.98%). The coverage rates of the currently available bivalent, quadrivalent, and nonavalent HPV vaccines were 5.18%, 66.84%, and 73.17%, respectively. However, these vaccines do not cover HPV51, HPV39, HPV59, HPV56, HPV53, HPV43, and HPV61, which are highly prevalent genotypes in the Chinese population.</p><p><strong>Conclusion: </strong>These findings highlight the urgent need for developing and promoting HPV vaccines tailored to the Chinese population and accelerating HPV vaccination programs among adolescents. Integrating male HPV vaccination into the national immunization program could significantly reduce the burden of HPV-related infections and diseases.</p>\",\"PeriodicalId\":23616,\"journal\":{\"name\":\"Virology Journal\",\"volume\":\"22 1\",\"pages\":\"238\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257770/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virology Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12985-025-02861-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02861-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
Trends in the molecular epidemiology of human papillomavirus in males from the plateau region of Southwest China: an 11-year retrospective analysis (2014-2024).
Background: Persistent high-risk human papillomavirus (HR-HPV) infection may increase the risk of malignancies in males, including penile, rectal, anal, prostate, bladder, and oropharyngeal cancers. However, few studies focused on the epidemiology of human papillomavirus (HPV) in male patients. This study aims to retrospectively investigate the trends of HPV molecular epidemiology in males residing in the plateau region of Southwest China from 2014 to 2024.
Methods: This retrospective study investigated the trends of HPV molecular epidemiology in 3580 males residing in the plateau region of southwest China from 2014 to 2024. Samples were collected for DNA extraction, and detection of 27 HPV genotypes by Luminex xMAP technology.
Results: HPV prevalence fluctuated between 43.17% and 56.02% over the 11 years, with an average prevalence of 50.28% (1800/3580, 95% CI: 48.64%-51.92%). Among infected individuals, LR-HPV alone, HR-HPV alone, and mixed infection accounted for 71.00%, 9.83%, and 19.17%, respectively. Single, dual, triple, quadruple, and other multiple infections accounted for 73.22%, 18.28%, 5.33%, 2.22%, and 0.95%, respectively. HPV prevalence varied by clinical diagnosis: the highest in warts (76.99%, 1114/1447), followed by neoplasms (67.15%, 92/137), other diagnoses (39.10%, 364/931), rash (30.17%, 73/242), urinary inflammation (24.23%, 47/194), and asymptomatic individuals (17.49%, 110/629). Age-specific HPV prevalence exhibited a U-shaped bimodal pattern. The top five HR-HPV genotypes were HPV16 (2.35%), HPV59 (2.18%), HPV52 (1.68%), HPV56 (1.54%), and HPV39 (1.48%), while the top three LR-HPV genotypes were HPV6 (26.45%), HPV11 (16.82%), and HPV43 (1.98%). The coverage rates of the currently available bivalent, quadrivalent, and nonavalent HPV vaccines were 5.18%, 66.84%, and 73.17%, respectively. However, these vaccines do not cover HPV51, HPV39, HPV59, HPV56, HPV53, HPV43, and HPV61, which are highly prevalent genotypes in the Chinese population.
Conclusion: These findings highlight the urgent need for developing and promoting HPV vaccines tailored to the Chinese population and accelerating HPV vaccination programs among adolescents. Integrating male HPV vaccination into the national immunization program could significantly reduce the burden of HPV-related infections and diseases.
期刊介绍：
Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies.
The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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