Berna Uzunoğlu, Emre Fırat, İrem Karadeniz, Figen Çelebi Çelik, Canan Şule Ünsal Karkıner, Özlem Sancaklı, Demet Can
{"title":"感觉加工障碍可能是儿童哮喘的合并症：一项横断面研究。","authors":"Berna Uzunoğlu, Emre Fırat, İrem Karadeniz, Figen Çelebi Çelik, Canan Şule Ünsal Karkıner, Özlem Sancaklı, Demet Can","doi":"10.1002/ppul.71203","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Asthma is a chronic inflammatory disease affecting multiple organ systems, including the central nervous system (CNS). Recent studies suggest an association between asthma and neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Sensory processing disorder (SPD), a neurodevelopmental condition characterized by atypical responses to sensory stimuli, may also be linked to asthma through shared inflammatory mechanisms.</p><p><strong>Objective: </strong>This study aimed to investigate the prevalence of SPD in children with asthma as compared to those without asthma and explore its relationship with asthma severity.</p><p><strong>Methods: </strong>This prospective, cross-sectional study included 182 children aged 5-12 years, with 91 asthmatic children in the study group and 91 nonasthmatic children in the control group. Sensory processing abilities were assessed using the Sensory Processing Measure (SPM) Home-Form. Statistical analyses, including logistic regression and path analysis, were performed to evaluate the association between asthma and sensory processing abnormalities.</p><p><strong>Results: </strong>Atypical sensory processing was significantly more prevalent in asthmatic children compared to the control group across multiple sensory domains, including vision, auditory, tactile, body awareness, balance, and movement (p < 0.005). Logistic regression analysis revealed that asthma was associated with increased risk of atypical sensory processing, particularly in tactile (OR: 5.716, 95% CI: 2.9-11.3 p < 0.001) and balance/movement (OR: 8.8, 95% CI: 2.5-30.7, p = 0.001) domains. However, no significant association was found between asthma severity and SPD prevalence.</p><p><strong>Conclusion: </strong>Our findings suggest that children with asthma exhibit a higher prevalence of SPD, supporting the hypothesis that neuroinflammation may contribute to sensory processing abnormalities. These results highlight the need for multidisciplinary approaches in managing asthmatic children, considering both respiratory and neurodevelopmental aspects. Further research is warranted to explore underlying mechanisms and potential interventions.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 7","pages":"e71203"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sensory Processing Disorder Could Be a Comorbidity of Childhood Asthma: A Cross-Sectional Study.\",\"authors\":\"Berna Uzunoğlu, Emre Fırat, İrem Karadeniz, Figen Çelebi Çelik, Canan Şule Ünsal Karkıner, Özlem Sancaklı, Demet Can\",\"doi\":\"10.1002/ppul.71203\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Asthma is a chronic inflammatory disease affecting multiple organ systems, including the central nervous system (CNS). Recent studies suggest an association between asthma and neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Sensory processing disorder (SPD), a neurodevelopmental condition characterized by atypical responses to sensory stimuli, may also be linked to asthma through shared inflammatory mechanisms.</p><p><strong>Objective: </strong>This study aimed to investigate the prevalence of SPD in children with asthma as compared to those without asthma and explore its relationship with asthma severity.</p><p><strong>Methods: </strong>This prospective, cross-sectional study included 182 children aged 5-12 years, with 91 asthmatic children in the study group and 91 nonasthmatic children in the control group. Sensory processing abilities were assessed using the Sensory Processing Measure (SPM) Home-Form. Statistical analyses, including logistic regression and path analysis, were performed to evaluate the association between asthma and sensory processing abnormalities.</p><p><strong>Results: </strong>Atypical sensory processing was significantly more prevalent in asthmatic children compared to the control group across multiple sensory domains, including vision, auditory, tactile, body awareness, balance, and movement (p < 0.005). Logistic regression analysis revealed that asthma was associated with increased risk of atypical sensory processing, particularly in tactile (OR: 5.716, 95% CI: 2.9-11.3 p < 0.001) and balance/movement (OR: 8.8, 95% CI: 2.5-30.7, p = 0.001) domains. However, no significant association was found between asthma severity and SPD prevalence.</p><p><strong>Conclusion: </strong>Our findings suggest that children with asthma exhibit a higher prevalence of SPD, supporting the hypothesis that neuroinflammation may contribute to sensory processing abnormalities. These results highlight the need for multidisciplinary approaches in managing asthmatic children, considering both respiratory and neurodevelopmental aspects. Further research is warranted to explore underlying mechanisms and potential interventions.</p>\",\"PeriodicalId\":19932,\"journal\":{\"name\":\"Pediatric Pulmonology\",\"volume\":\"60 7\",\"pages\":\"e71203\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Pulmonology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ppul.71203\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71203","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Sensory Processing Disorder Could Be a Comorbidity of Childhood Asthma: A Cross-Sectional Study.
Background: Asthma is a chronic inflammatory disease affecting multiple organ systems, including the central nervous system (CNS). Recent studies suggest an association between asthma and neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Sensory processing disorder (SPD), a neurodevelopmental condition characterized by atypical responses to sensory stimuli, may also be linked to asthma through shared inflammatory mechanisms.
Objective: This study aimed to investigate the prevalence of SPD in children with asthma as compared to those without asthma and explore its relationship with asthma severity.
Methods: This prospective, cross-sectional study included 182 children aged 5-12 years, with 91 asthmatic children in the study group and 91 nonasthmatic children in the control group. Sensory processing abilities were assessed using the Sensory Processing Measure (SPM) Home-Form. Statistical analyses, including logistic regression and path analysis, were performed to evaluate the association between asthma and sensory processing abnormalities.
Results: Atypical sensory processing was significantly more prevalent in asthmatic children compared to the control group across multiple sensory domains, including vision, auditory, tactile, body awareness, balance, and movement (p < 0.005). Logistic regression analysis revealed that asthma was associated with increased risk of atypical sensory processing, particularly in tactile (OR: 5.716, 95% CI: 2.9-11.3 p < 0.001) and balance/movement (OR: 8.8, 95% CI: 2.5-30.7, p = 0.001) domains. However, no significant association was found between asthma severity and SPD prevalence.
Conclusion: Our findings suggest that children with asthma exhibit a higher prevalence of SPD, supporting the hypothesis that neuroinflammation may contribute to sensory processing abnormalities. These results highlight the need for multidisciplinary approaches in managing asthmatic children, considering both respiratory and neurodevelopmental aspects. Further research is warranted to explore underlying mechanisms and potential interventions.
期刊介绍：
Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases.
PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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