经过训练的狗能嗅出帕金森氏症的气味。

IF 5 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI:10.1177/1877718X251342485

Nicola Rooney, Drupad K Trivedi, Eleanor Sinclair, Caitlin Walton-Doyle, Monty Silverdale, Perdita Barran, Tilo Kunath, Steve Morant, Mark Somerville, Jayde Smith, Julie Jones-Diette, Jenny Corish, Joy Milne, Claire Guest

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引用次数: 0

摘要

帕金森病（PD）的明确诊断测试仍然难以捉摸，因此鉴定潜在的生物标志物可以促进诊断和早期干预。两只狗被训练来区分从帕金森病患者（PwP）和对照组获得的干皮肤拭子。在对205个样本进行了38-53周的训练后，这些狗接受了60个对照样本和40个目标样本（drug-naïve PwP）的双盲试验。它们分别具有高灵敏度（70%和80%）和特异性（90%和98%）。这支持了先前的发现，即狗可以被训练来可靠地检测PD的气味。

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Trained dogs can detect the odor of Parkinson's disease.

A definitive diagnostic test for Parkinson's disease (PD) remains elusive, so identification of potential biomarkers can facilitate diagnosis and early intervention. Two dogs were trained to distinguish between dry skin swabs obtained from people with Parkinson's (PwP) and control participants. After 38-53 weeks of training on 205 samples, the dogs were tested in a double-blind trial using 60 control and 40 target (drug-naïve PwP) samples. They each showed high sensitivity (70% and 80%) and specificity (90% and 98%). This supports previous findings that dogs can be trained to reliably detect the odor of PD.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.