一种预测慢性阻塞性肺疾病患者次优峰值吸入流量的评分系统的开发。

IF 2.3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Sang Hyuk Kim, Youlim Kim, Chin Kook Rhee, Hyun Lee, Chang Youl Lee, Joo Hun Park, Seung Won Ra, Yong Bum Park, Kwang Ha Yoo, Hee Joung Kim
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引用次数: 0

摘要

背景:峰值吸入流量(PIFR)是干粉吸入器(dpi)成功使用的关键指标。然而,资源限制往往限制了在DPI处方之前测量PIFR的实用性。方法:在韩国7家医院进行横断面观察性研究,包括慢性阻塞性肺疾病(COPD)患者。为了开发一个评分系统,在没有直接测量的情况下预测次优PIFR,考虑到临床环境的实用性,通过文献回顾和逻辑回归模型选择变量。结果:该研究纳入436例患者,按7:3的比例分为训练和测试数据集。选择年龄(≥80岁)、体重(≤60 kg)、修正医学研究委员会评分(≥2)和支气管扩张剂后用力肺活量(≤80%pred)制定评分系统。该评分系统的评分范围为0 - 4分,预测次优PIFR的阈值为2分,对训练中的次优PIFR具有可接受的预测能力(受训者操作特征下面积[AUROC], 0.724;95%置信区间[CI], 0.660-0.789)和检验数据集(AUROC, 0.686;95% ci, 0.591-0.781)。结论:我们开发的评分系统利用易于应用于临床实践的变量,对COPD患者的次优PIFR具有可接受的预测能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Development of a Scoring System to Predict Suboptimal Peak Inspiratory Flow in Patients With Chronic Obstructive Pulmonary Disease.

Development of a Scoring System to Predict Suboptimal Peak Inspiratory Flow in Patients With Chronic Obstructive Pulmonary Disease.

Development of a Scoring System to Predict Suboptimal Peak Inspiratory Flow in Patients With Chronic Obstructive Pulmonary Disease.

Development of a Scoring System to Predict Suboptimal Peak Inspiratory Flow in Patients With Chronic Obstructive Pulmonary Disease.

Background: Peak inspiratory flow rate (PIFR) is a critical indicator for the successful use of dry powder inhalers (DPIs). However, resource constraints often limit the practicality of measuring PIFR prior to DPI prescription.

Methods: A cross-sectional observational study was conducted across seven hospitals in Korea, including patients with chronic obstructive pulmonary disease (COPD). To develop a scoring system to predict suboptimal PIFR without direct measurement, variables were selected through a literature review and logistic regression model, considering practicality in clinical settings.

Results: The study involved 436 patients and was divided into training and test datasets with a 7:3 ratio. Age (≥ 80 years), weight (≤ 60 kg), modified Medical Research Council score (≥ 2), and post-bronchodilator forced vital capacity (≤ 80%pred) were selected to develop the scoring system. The developed scoring system, ranging from 0 to 4 points with a 2-points threshold for predicting suboptimal PIFR, demonstrated acceptable predictive ability for suboptimal PIFR in training (area under the receiver operating characteristic [AUROC], 0.724; 95% confidence interval [CI], 0.660-0.789) and test datasets (AUROC, 0.686; 95% CI, 0.591-0.781).

Conclusion: Our developed scoring system demonstrated an acceptable predictive ability for suboptimal PIFR in COPD patients, utilizing variables that are easily applicable in clinical practice.

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来源期刊
Journal of Korean Medical Science
Journal of Korean Medical Science 医学-医学:内科
CiteScore
7.80
自引率
8.90%
发文量
320
审稿时长
3-6 weeks
期刊介绍: The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.
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