Jongmin Oh, Gonzalo Hevia-Ramos, Eunhee Ha, Yun-Chul Hong, Hyun Kim, Youn-Hee Lim
{"title":"亚太国家长期暴露于颗粒物与全因和特定原因死亡率的系统回顾和荟萃分析。","authors":"Jongmin Oh, Gonzalo Hevia-Ramos, Eunhee Ha, Yun-Chul Hong, Hyun Kim, Youn-Hee Lim","doi":"10.3346/jkms.2025.40.e156","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Global Burden of Disease (GBD) studies have proposed integrated exposure-response models primarily based on North American and European data, which may not be directly applicable to the Asia-Pacific region. Through a systematic review and meta-analysis, we aimed to explore the association between long-term exposure to ambient particulate matter (PM) and mortality in the Asia-Pacific states.</p><p><strong>Methods: </strong>We searched 3 databases (PubMed [n = 8,326], Embase [n = 4,709], and Cochrane Library [n = 357]) between 1st January 1990 and 31st July 2023. Our search focused on studies examining the associations between long-term exposure to PM with an aerodynamic diameter < 2.5 μm (PM<sub>2.5</sub>) and 10 μm (PM₁₀) and all-cause (or non-accidental) and cause-specific mortality, including cardiovascular disease (CVD), ischemic heart disease (IHD), stroke, acute lower respiratory infection, chronic obstructive pulmonary disease, and lung cancer deaths in the Asia-Pacific states. We conducted a meta-analysis to pool the estimates in the studies.</p><p><strong>Results: </strong>We identified 71 articles investigating the association between long-term exposure to PM and all-cause and cause-specific mortality. For a 10 μg/m³ increase in PM<sub>2.5</sub>, the pooled relative risk (RR) with 95% confidence intervals (CI) for all-cause mortality was 1.11 (95% CI, 1.05-1.17), 1.13 (95% CI, 1.06-1.21) for CVD, 1.13 (95% CI, 1.02-1.25) for IHD, 1.12 (95% CI, 1.02-1.24) for stroke, and 1.12 (95% CI, 1.08-1.16) for lung cancer. For a 10 μg/m³ increase in PM₁₀, the pooled RR for all-cause mortality was 1.12 (95% CI, 1.00-1.24) and 1.33 (95% CI, 1.28-1.38) for IHD.</p><p><strong>Conclusion: </strong>Our analysis revealed positive associations between long-term exposure to PM and all-cause and cause-specific mortality for CVD, IHD, stroke, and lung cancer in the Asia-Pacific states.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42023441916.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 27","pages":"e156"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260597/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.\",\"authors\":\"Jongmin Oh, Gonzalo Hevia-Ramos, Eunhee Ha, Yun-Chul Hong, Hyun Kim, Youn-Hee Lim\",\"doi\":\"10.3346/jkms.2025.40.e156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Global Burden of Disease (GBD) studies have proposed integrated exposure-response models primarily based on North American and European data, which may not be directly applicable to the Asia-Pacific region. Through a systematic review and meta-analysis, we aimed to explore the association between long-term exposure to ambient particulate matter (PM) and mortality in the Asia-Pacific states.</p><p><strong>Methods: </strong>We searched 3 databases (PubMed [n = 8,326], Embase [n = 4,709], and Cochrane Library [n = 357]) between 1st January 1990 and 31st July 2023. Our search focused on studies examining the associations between long-term exposure to PM with an aerodynamic diameter < 2.5 μm (PM<sub>2.5</sub>) and 10 μm (PM₁₀) and all-cause (or non-accidental) and cause-specific mortality, including cardiovascular disease (CVD), ischemic heart disease (IHD), stroke, acute lower respiratory infection, chronic obstructive pulmonary disease, and lung cancer deaths in the Asia-Pacific states. We conducted a meta-analysis to pool the estimates in the studies.</p><p><strong>Results: </strong>We identified 71 articles investigating the association between long-term exposure to PM and all-cause and cause-specific mortality. For a 10 μg/m³ increase in PM<sub>2.5</sub>, the pooled relative risk (RR) with 95% confidence intervals (CI) for all-cause mortality was 1.11 (95% CI, 1.05-1.17), 1.13 (95% CI, 1.06-1.21) for CVD, 1.13 (95% CI, 1.02-1.25) for IHD, 1.12 (95% CI, 1.02-1.24) for stroke, and 1.12 (95% CI, 1.08-1.16) for lung cancer. For a 10 μg/m³ increase in PM₁₀, the pooled RR for all-cause mortality was 1.12 (95% CI, 1.00-1.24) and 1.33 (95% CI, 1.28-1.38) for IHD.</p><p><strong>Conclusion: </strong>Our analysis revealed positive associations between long-term exposure to PM and all-cause and cause-specific mortality for CVD, IHD, stroke, and lung cancer in the Asia-Pacific states.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42023441916.</p>\",\"PeriodicalId\":16249,\"journal\":{\"name\":\"Journal of Korean Medical Science\",\"volume\":\"40 27\",\"pages\":\"e156\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260597/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Korean Medical Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3346/jkms.2025.40.e156\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3346/jkms.2025.40.e156","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.
Background: Global Burden of Disease (GBD) studies have proposed integrated exposure-response models primarily based on North American and European data, which may not be directly applicable to the Asia-Pacific region. Through a systematic review and meta-analysis, we aimed to explore the association between long-term exposure to ambient particulate matter (PM) and mortality in the Asia-Pacific states.
Methods: We searched 3 databases (PubMed [n = 8,326], Embase [n = 4,709], and Cochrane Library [n = 357]) between 1st January 1990 and 31st July 2023. Our search focused on studies examining the associations between long-term exposure to PM with an aerodynamic diameter < 2.5 μm (PM2.5) and 10 μm (PM₁₀) and all-cause (or non-accidental) and cause-specific mortality, including cardiovascular disease (CVD), ischemic heart disease (IHD), stroke, acute lower respiratory infection, chronic obstructive pulmonary disease, and lung cancer deaths in the Asia-Pacific states. We conducted a meta-analysis to pool the estimates in the studies.
Results: We identified 71 articles investigating the association between long-term exposure to PM and all-cause and cause-specific mortality. For a 10 μg/m³ increase in PM2.5, the pooled relative risk (RR) with 95% confidence intervals (CI) for all-cause mortality was 1.11 (95% CI, 1.05-1.17), 1.13 (95% CI, 1.06-1.21) for CVD, 1.13 (95% CI, 1.02-1.25) for IHD, 1.12 (95% CI, 1.02-1.24) for stroke, and 1.12 (95% CI, 1.08-1.16) for lung cancer. For a 10 μg/m³ increase in PM₁₀, the pooled RR for all-cause mortality was 1.12 (95% CI, 1.00-1.24) and 1.33 (95% CI, 1.28-1.38) for IHD.
Conclusion: Our analysis revealed positive associations between long-term exposure to PM and all-cause and cause-specific mortality for CVD, IHD, stroke, and lung cancer in the Asia-Pacific states.
期刊介绍:
The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.