亚太国家长期暴露于颗粒物与全因和特定原因死亡率的系统回顾和荟萃分析。

IF 2.3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Jongmin Oh, Gonzalo Hevia-Ramos, Eunhee Ha, Yun-Chul Hong, Hyun Kim, Youn-Hee Lim
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引用次数: 0

摘要

背景:全球疾病负担(GBD)研究提出了主要基于北美和欧洲数据的综合暴露-反应模型,这可能并不直接适用于亚太地区。通过系统回顾和荟萃分析,我们旨在探讨亚太国家长期暴露于环境颗粒物(PM)与死亡率之间的关系。方法:检索1990年1月1日至2023年7月31日的PubMed [n = 8326]、Embase [n = 4709]和Cochrane Library [n = 357] 3个数据库。我们的研究重点是研究长期暴露于空气动力学直径< 2.5 μm (PM2.5)和10 μm (PM₁0)的PM与全因(或非意外)和原因特异性死亡率之间的关系,包括心血管疾病(CVD),缺血性心脏病(IHD),中风,急性下呼吸道感染,慢性阻塞性肺病和肺癌死亡在亚太国家。我们进行了荟萃分析,汇总了研究中的估计。结果:我们确定了71篇研究长期暴露于PM与全因和病因特异性死亡率之间关系的文章。PM2.5每增加10 μg/m³,全因死亡率的总相对危险度(RR) 95%可信区间(CI)分别为:心血管疾病1.11 (95% CI, 1.05-1.17)、心血管疾病1.13 (95% CI, 1.06-1.21)、IHD 1.13 (95% CI, 1.02-1.25)、中风1.12 (95% CI, 1.02-1.24)、肺癌1.12 (95% CI, 1.08-1.16)。对于PM 10增加10 μg/m³,IHD的全因死亡率的总RR为1.12 (95% CI, 1.00-1.24)和1.33 (95% CI, 1.28-1.38)。结论:我们的分析显示,长期暴露于PM与亚太国家CVD、IHD、中风和肺癌的全因死亡率和病因特异性死亡率呈正相关。试验注册:PROSPERO标识符:CRD42023441916。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.

A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.

A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.

A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States.

Background: Global Burden of Disease (GBD) studies have proposed integrated exposure-response models primarily based on North American and European data, which may not be directly applicable to the Asia-Pacific region. Through a systematic review and meta-analysis, we aimed to explore the association between long-term exposure to ambient particulate matter (PM) and mortality in the Asia-Pacific states.

Methods: We searched 3 databases (PubMed [n = 8,326], Embase [n = 4,709], and Cochrane Library [n = 357]) between 1st January 1990 and 31st July 2023. Our search focused on studies examining the associations between long-term exposure to PM with an aerodynamic diameter < 2.5 μm (PM2.5) and 10 μm (PM₁₀) and all-cause (or non-accidental) and cause-specific mortality, including cardiovascular disease (CVD), ischemic heart disease (IHD), stroke, acute lower respiratory infection, chronic obstructive pulmonary disease, and lung cancer deaths in the Asia-Pacific states. We conducted a meta-analysis to pool the estimates in the studies.

Results: We identified 71 articles investigating the association between long-term exposure to PM and all-cause and cause-specific mortality. For a 10 μg/m³ increase in PM2.5, the pooled relative risk (RR) with 95% confidence intervals (CI) for all-cause mortality was 1.11 (95% CI, 1.05-1.17), 1.13 (95% CI, 1.06-1.21) for CVD, 1.13 (95% CI, 1.02-1.25) for IHD, 1.12 (95% CI, 1.02-1.24) for stroke, and 1.12 (95% CI, 1.08-1.16) for lung cancer. For a 10 μg/m³ increase in PM₁₀, the pooled RR for all-cause mortality was 1.12 (95% CI, 1.00-1.24) and 1.33 (95% CI, 1.28-1.38) for IHD.

Conclusion: Our analysis revealed positive associations between long-term exposure to PM and all-cause and cause-specific mortality for CVD, IHD, stroke, and lung cancer in the Asia-Pacific states.

Trial registration: PROSPERO Identifier: CRD42023441916.

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来源期刊
Journal of Korean Medical Science
Journal of Korean Medical Science 医学-医学:内科
CiteScore
7.80
自引率
8.90%
发文量
320
审稿时长
3-6 weeks
期刊介绍: The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.
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