钩藤钩茎水煎液中提取的少量内酯。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI:10.1080/10286020.2025.2525322

Fang-Ting Wei, Le-Ling Song, Jin-Qiu Ren, Xiao-Qiang Lei, Qing-Lan Guo, Jian-Gong Shi

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引用次数: 0

摘要

从钩藤（Uncaria rhynchophyla, gouteng）钩茎水煎液中分离得到6个未描述的微量内酯（uncarterolides a - f, 1-6）。通过光谱数据分析、电子圆二色性（ECD）和核磁共振计算确定了它们的结构。化合物3 ~ 6为异常同型单萜烯醛内酯，结构特征与猪藤单萜生物碱相同，化合物3、6可将apap诱导的HepG2细胞损伤从59.39%提高到75.87%和74.43%。

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Minor lactones from a water decoction of the hook-bearing stem of Uncaria rhynchophylla.

Six undescribed minor lactones (uncarterolides A-F, 1-6) were isolated from a water decoction of the hook-bearing stems of Uncaria rhynchophylla (gou-teng). Their structures were determined by spectroscopic data analysis, along with electronic circular dichroism (ECD) and NMR calculations. Compounds 3-6 are abnormal homo-monoterpene enolic ether lactones sharing structural features with monoterpene alkaloids from gou-teng, as well as compounds 3 and 6 attenuated APAP-induced HepG2 cell damage by increasing the cell viability from 59.39% to 75.87% and 74.43%, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.