展望毒液库:一个研究毒液及其应用的综合知识库。

IF 2.2 4区 生物学 Q2 BIOLOGY
Integrative Organismal Biology Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.1093/iob/obaf026
T A Castoe, M Daly, F Jungo, K N Kirchhoff, I Koludarov, S Mackessy, J Macrander, S Mehr, M V Modica, E E Sanchez, G Zancolli, M Holford
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引用次数: 0

摘要

毒液是复杂的生物活性混合物,在不同的动物谱系中独立进化,包括蜗牛、昆虫、海葵、蜘蛛、蝎子和蛇。尽管人们对毒液研究越来越感兴趣,但数据分散在不同的数据库中,缺乏标准化和互操作性。这里提出的VenomsBase平台的愿景是通过使用最佳实践方法来创建一个遵循FAIR原则(可查找、可访问、可互操作和可复制)的集中式开放访问平台,从而解决这些挑战。VenomsBase将统一毒液数据集,标准化术语,并实现跨物种的比较分析,促进新毒素的发现和功能注释。VenomsBase的主要功能包括用户友好的数据提交模块,内置验证,先进的跨物种分析工具,以及跨基因组学,转录组学,蛋白质组学,功能分析和生态元数据的多学科数据集的集成。模块化、基于云的设计将确保可扩展性,而启发式评分系统将引导用户获得高可信度的数据条目。为了提高可访问性,设想中的VenomsBase将提供教程、定期培训课程、案例研究和反馈循环,为各级研究人员提供支持。通过协调毒液研究和解决过时或非标准化方法的局限性,VenomsBase旨在彻底改变该领域,同时由毒液专家不断改进和完善。这一倡议将释放毒液的潜力,以取得突破性发现,应对全球卫生挑战,并促进科学界的合作与创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Vision for VenomsBase: An Integrated Knowledgebase for the Study of Venoms and Their Applications.

Venoms are complex bioactive mixtures that have independently evolved across diverse animal lineages, including snails, insects, sea anemones, spiders, scorpions, and snakes. Despite the growing interest in venom research, data is fragmented across disparate databases which lack standardization and interoperability. A vision for the proposed VenomsBase platform presented here seeks to address these challenges by using the best practices approach in creating a centralized, open-access platform adhering to FAIR principles (Findable, Accessible, Interoperable, and Reproducible). VenomsBase will unify venom datasets, standardize terminology, and enable comparative analyses across species, facilitating novel toxin discovery and functional annotation. Key features of VenomsBase include user-friendly data submission modules with built-in validation, advanced cross-species analysis tools, and integration of multidisciplinary datasets spanning genomics, transcriptomics, proteomics, functional assays, and ecological metadata. A modular, cloud-based design will ensure scalability, while heuristic scoring systems will guide users toward high-confidence data entries. To promote accessibility, the envisioned VenomsBase will provide tutorials, regular training sessions, case studies, and feedback loops, supporting researchers at all levels. By harmonizing venom research and addressing the limitations of outdated or nonstandardized methods, VenomsBase aims to revolutionize the field, while being continuously improved and refined by venom experts. This initiative will unlock venoms' potential to make groundbreaking discoveries, address global health challenges, and foster collaboration and innovation across the scientific community.

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来源期刊
CiteScore
3.70
自引率
6.70%
发文量
48
审稿时长
20 weeks
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