{"title":"中性粒细胞/淋巴细胞比值和单核细胞/淋巴细胞比值与狼疮性肾炎患者肾损伤的关系。","authors":"Dantong Wu, Yao Wang, Xiao Han, Haiyan Gao, Yue Zhang, Hongjun Lou","doi":"10.7754/Clin.Lab.2025.241217","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the correlation between the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) with renal injury in patients with lupus nephritis (LN).</p><p><strong>Methods: </strong>Data was obtained from 26 patients with LN and 72 with systemic lupus erythematosus (SLE) who received treatment between January 2021 and October 2022 at the First Hospital of Heilongjiang University of Traditional Chinese Medicine. Venous blood was collected from the patients. We determined blood urea, creatinine (Cr), cystatin C (CYSC), and uric acid (UA) and calculated the NLR, MLR, and PLR.</p><p><strong>Results: </strong>The NLR and MLR were significantly greater in the LN group compared to SLE group (p < 0.05). Spearman's correlation analysis demonstrated that MLR had a positive correlation with UA (p < 0.05), while PLR ex-hibited a positive correlation with Cr and UA (p < 0.05). The NLR and MLR p-values were less than 0.05, and the respective areas under the receiver operating characteristic (ROC) curves for each were 0.761 and 0.720.</p><p><strong>Conclusions: </strong>NLR and MLR are strongly related to renal injury in patients with LN. These ratios demonstrate a reasonable correlation with the commonly used markers of renal injury and have significant clinical value in evaluating impaired renal function in such patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 7","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio Concerning Renal Injury in Patients with Lupus Nephritis.\",\"authors\":\"Dantong Wu, Yao Wang, Xiao Han, Haiyan Gao, Yue Zhang, Hongjun Lou\",\"doi\":\"10.7754/Clin.Lab.2025.241217\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The aim of this study was to investigate the correlation between the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) with renal injury in patients with lupus nephritis (LN).</p><p><strong>Methods: </strong>Data was obtained from 26 patients with LN and 72 with systemic lupus erythematosus (SLE) who received treatment between January 2021 and October 2022 at the First Hospital of Heilongjiang University of Traditional Chinese Medicine. Venous blood was collected from the patients. We determined blood urea, creatinine (Cr), cystatin C (CYSC), and uric acid (UA) and calculated the NLR, MLR, and PLR.</p><p><strong>Results: </strong>The NLR and MLR were significantly greater in the LN group compared to SLE group (p < 0.05). Spearman's correlation analysis demonstrated that MLR had a positive correlation with UA (p < 0.05), while PLR ex-hibited a positive correlation with Cr and UA (p < 0.05). The NLR and MLR p-values were less than 0.05, and the respective areas under the receiver operating characteristic (ROC) curves for each were 0.761 and 0.720.</p><p><strong>Conclusions: </strong>NLR and MLR are strongly related to renal injury in patients with LN. These ratios demonstrate a reasonable correlation with the commonly used markers of renal injury and have significant clinical value in evaluating impaired renal function in such patients.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 7\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2025.241217\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2025.241217","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio Concerning Renal Injury in Patients with Lupus Nephritis.
Background: The aim of this study was to investigate the correlation between the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) with renal injury in patients with lupus nephritis (LN).
Methods: Data was obtained from 26 patients with LN and 72 with systemic lupus erythematosus (SLE) who received treatment between January 2021 and October 2022 at the First Hospital of Heilongjiang University of Traditional Chinese Medicine. Venous blood was collected from the patients. We determined blood urea, creatinine (Cr), cystatin C (CYSC), and uric acid (UA) and calculated the NLR, MLR, and PLR.
Results: The NLR and MLR were significantly greater in the LN group compared to SLE group (p < 0.05). Spearman's correlation analysis demonstrated that MLR had a positive correlation with UA (p < 0.05), while PLR ex-hibited a positive correlation with Cr and UA (p < 0.05). The NLR and MLR p-values were less than 0.05, and the respective areas under the receiver operating characteristic (ROC) curves for each were 0.761 and 0.720.
Conclusions: NLR and MLR are strongly related to renal injury in patients with LN. These ratios demonstrate a reasonable correlation with the commonly used markers of renal injury and have significant clinical value in evaluating impaired renal function in such patients.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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