丙烯基硫胺与亚胺碘胺反应一步合成n -磺酰-2,3-二氢-1,2-噻唑。

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.104

Vladimir G Ilkin, Pavel S Silaichev, Valeriy O Filimonov, Tetyana V Beryozkina, Margarita D Likhacheva, Pavel A Slepukhin, Wim Dehaen, Vasiliy A Bakulev

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引用次数: 0

摘要

研究了丙烯硫胺与亚胺碘胺一步法合成2,3-二氢-2-磺酰基-3,4,5-取代1,2-噻唑的方法。以高收率合成了31个四取代1,2-噻唑类化合物。用克数的起始硫胺对反应进行缩放，证实了该合成方法对这些研究较少的1,2-噻唑的有效性。

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Reactions of acryl thioamides with iminoiodinanes as a one-step synthesis of N-sulfonyl-2,3-dihydro-1,2-thiazoles.

A one-step method has been developed for the preparation of 2,3-dihydro-2-sulfonyl-3,4,5-substituted 1,2-thiazoles by the reaction of acryl thioamides and iminoiodinanes. A library of 31 examples of tetrasubstituted 1,2-thiazoles was thus synthesized in high yields. The effectiveness of the synthesis method for these poorly studied 1,2-thiazoles was confirmed by scaling the reaction using gram amounts of the starting thioamide.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.