透析过程中使用创新的直接溶解技术的高浓度氢输送:犬模型的体内动力学。

IF 3.1 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Kenji Tani, Yukihiro Hitaka, Kimihiko Nakamura, Naohito Isoyama, Zenzo Fujii, Motoaki Sano
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引用次数: 0

摘要

氢气(H₂)具有广泛的治疗潜力。血液透析是利用与血液接触的大量透析液的一种很有前途的H₂输送方法。我们开发了一个创新的系统,产生富氢的透析液,不同于传统的电解。该系统将氢气直接溶解到自来水中,产生饱和水,然后通过反渗透(RO)制备透析液。在犬血液透析模型中使用该系统,我们测量了H₂浓度。高H₂水平持续保持(RO水中约1600 ppb;最终透析液稳定在230 PPB左右)。H₂有效地扩散到体外血液循环中,出口浓度达到透析液水平的54.0-67.7%。然而,较低的全身动脉浓度(肺、颈动脉)表明明显的肺清除率,表明H₂主要在回路和透析器内局部起作用。与传统的电解水方法相比,这种直接溶解系统提供了更高和更稳定的H₂浓度。它更简单的设计和潜在的更低的安装成本表明了广泛临床应用的可行性。未来的研究应探索血液滤过(HDF),以潜在地增强全身H₂输送并评估长期临床益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Concentration Hydrogen Delivery During Dialysis Using an Innovative Direct Dissolution Technique: In Vivo Kinetics in a Canine Model.

Hydrogen gas (H₂) shows broad therapeutic potential. Hemodialysis, using large dialysate volumes in contact with blood, presents a promising H₂ delivery method. We developed an innovative system generating hydrogen-enriched dialysate, differing from conventional electrolysis. This system directly dissolves H₂ gas into tap water to produce saturated water, which then undergoes reverse osmosis (RO) for dialysate preparation. Using this system in a canine hemodialysis model with a single dog, we measured H₂ concentrations. High H₂ levels were consistently maintained (approximately 1,600 ppb in RO water; stable approximately 230 ppb in final dialysate). H₂ efficiently diffused into the extracorporeal blood circuit, with outlet concentrations reaching 54.0-67.7% of the dialysate level. However, low systemic arterial concentrations (pulmonary, carotid) indicated significant pulmonary clearance, suggesting H₂ primarily acts locally within the circuit and dialyzer. Compared with traditional electrolyzed water methods, this direct dissolution system delivers substantially higher and more stable H₂ concentrations. Its simpler design and potentially lower installation costs suggest feasibility for widespread clinical adoption. Future studies should explore hemodiafiltration (HDF) to potentially enhance systemic H₂ delivery and evaluate long-term clinical benefits.

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来源期刊
ASAIO Journal
ASAIO Journal 医学-工程:生物医学
CiteScore
6.60
自引率
7.10%
发文量
651
审稿时长
4-8 weeks
期刊介绍: ASAIO Journal is in the forefront of artificial organ research and development. On the cutting edge of innovative technology, it features peer-reviewed articles of the highest quality that describe research, development, the most recent advances in the design of artificial organ devices and findings from initial testing. Bimonthly, the ASAIO Journal features state-of-the-art investigations, laboratory and clinical trials, and discussions and opinions from experts around the world. The official publication of the American Society for Artificial Internal Organs.
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