主族元素酞菁在光/声驱动癌症治疗中的结构-性质关系

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2025-07-16 DOI:10.1016/j.ccr.2025.216969

Zhaoyang Liu , Xintong Lin , Hanqiang Wang , Pingyu Zhang

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引用次数: 0

摘要

酞菁是公认的第二代光敏剂，由于其较强的近红外吸收和结构的通用性，在光动力治疗（PDT）、光热治疗（PTT）和声动力治疗（SDT）方面特别有前景。虽然审查主要集中在过渡金属酞菁，但对主要类酞菁的系统调查仍然很少。为了弥补这一空白，本文系统地研究了含有IIA族（Mg, Ca, Sr, Ba）， IIIA族（Al, Ga, In, Tl）， IVA族（Si, Ge, Sn, Pb）和VA族（P, As, Sb, Bi）主要族元素的酞菁配合物的化学结构和生物医学潜力。通过对其独特的特性和在光/声驱动治疗中的潜力进行综述，不仅可以激发癌症治疗的进一步研究和创新，而且可以促进下一代生物医学策略的发展。

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Structure-property relationships of main-group element phthalocyanines in photo/sono-driven cancer therapy

Phthalocyanines, recognized as second-generation photosensitizers, are particularly promising for photodynamic therapy (PDT), photothermal therapy (PTT), and sonodynamic therapy (SDT) due to their strong NIR absorption and structural versatility. While reviews predominantly focus on transition metal phthalocyanines, a systematic survey on main-group phthalocyanines remains scarce. In order to address this gap, this review systematically examines the chemical structures and biomedical potential of phthalocyanine complexes containing main group elements from groups IIA (Mg, Ca, Sr, Ba), IIIA (Al, Ga, In, Tl), IVA (Si, Ge, Sn, Pb), and VA (P, As, Sb, Bi). By highlighting their unique properties and potential on photo/sono-driven therapy, this review aims to not only inspire further research and innovation in cancer therapy but also foster the development of next-generation biomedical strategies.

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.