在Suzuki-Miyaura交叉偶联中参与脂肪族甲酰基化合物的后期功能化

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-03 DOI:10.1016/j.tet.2025.134805

Chloe D. Wong, Lauren C. Bradford, Elizabeth R. Jarvo

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引用次数: 0

摘要

利用现成起始材料的后期功能化反应对于合成用途是有价值的。鉴于醇在药物、天然产物中的普遍存在，以及它们的商业可用性，促进脂肪醇衍生物的C-O键转化为C-C键的偶联反应是非常有用的。本文中，我们描述了脂肪族甲磺酸酯与芳基硼酸的Suzuki-Miyaura交叉偶联反应，作为天然产物衍生物和药学相关分子的后期功能化方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Engaging aliphatic mesylates in Suzuki-Miyaura cross-coupling for late-stage functionalization

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Engaging aliphatic mesylates in Suzuki-Miyaura cross-coupling for late-stage functionalization

Late-stage functionalization reactions leveraging readily available starting materials are valuable for synthetic utility. Given the prevalence of alcohols in medicinal agents, natural products, and their commercial availability, coupling reactions facilitating the transformation of C–O bonds of aliphatic alcohol derivatives to C–C bonds are quite useful. Herein, we describe a Suzuki-Miyaura cross-coupling reaction of aliphatic mesylates with aryl boronic acids as a method for the late-stage functionalization of natural product derivatives and pharmaceutically relevant molecules.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.