一种创新的化合物，通过动员牙龈间充质干细胞归巢促进口腔伤口愈合

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-07-15 DOI:10.1016/j.bbrep.2025.102154

Lei Yang , Yue Song , Yao Jiao , Siyan Liu , Yi Liu , Lijia Guo , Yitong Liu

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引用次数: 0

摘要

口腔伤口愈合是一个复杂的生物过程，涉及炎症、增殖和组织重塑。龈间充质干细胞（GMSCs）由于其再生潜能和免疫调节特性在这一过程中起着至关重要的作用。本研究考察了真菌源性生物活性化合物Purpurolide C （PC）是否通过促进GMSCs的迁移能力来促进口腔创面愈合。在体外，PC增强了GMSC的迁移、多能性和成骨分化。在体内，小鼠腭软组织缺损模型表明，PC显著加速伤口愈合，增加GMSC向伤口部位的募集。此外，16S rRNA测序显示，PC给药不会破坏肠道微生物群的稳态。这些结果表明，PC是一种很有前景的促进口腔伤口愈合的治疗药物，为再生医学的潜在临床应用铺平了道路。

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An innovative compound that promotes oral wound healing via mobilizing gingival mesenchymal stem cell homing

Oral wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Gingival mesenchymal stem cells (GMSCs) play a crucial role in this process due to their regenerative potential and immunomodulatory properties. This study investigated whether Purpurolide C (PC), a fungal-derived bioactive compound, could promote oral wound healing by promoting the migratory ability of GMSCs. In vitro, PC enhanced GMSC migration, pluripotency, and osteogenic differentiation. In vivo, a mouse palatal soft tissue defect model demonstrated that PC significantly accelerated wound closure and increased GMSC recruitment to the wound site. Furthermore, 16S rRNA sequencing revealed that PC administration did not disrupt gut microbiota homeostasis. These findings suggest that PC is a promising therapeutic agent for enhancing oral wound healing, paving the way for potential clinical applications in regenerative medicine.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.