用于羧酸室温直接酰胺化的双功能硼酸/磷(V)有机催化剂

IF 11.5 Q1 CHEMISTRY, PHYSICAL

Chem Catalysis Pub Date : 2025-07-15 DOI:10.1016/j.checat.2025.101460

Kimberly A.W. Reid, Randy Sutio, Jack M. Ranani, Maksym Pavlenko, Brennah E. Slaney, Christophe Allais, Johnny W. Lee, Christopher Sandford

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引用次数: 0

摘要

在温和条件下可持续合成酰胺键是制药过程工业的一个关键绿色化学目标，也是美国化学会绿色化学研究所药物圆桌会议的十个目标之一。在这里，我们报道了一种可以在室温下合成酰胺的有机催化剂。催化剂包括硼酸和氧化膦两种功能，它们协同作用以促进底物活化。与其他芳基硼酸催化剂不同，单体机制通过氧化还原-中性磷(V)循环进行，其中相邻的硼酸是室温活性的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A bifunctional boronic acid/phosphorus(V) organocatalyst for the direct room-temperature amidation of carboxylic acids

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A bifunctional boronic acid/phosphorus(V) organocatalyst for the direct room-temperature amidation of carboxylic acids

The sustainable synthesis of amide bonds under mild conditions is a key green chemistry target for the pharmaceutical process industry and is highlighted as one of the ten goals of the American Chemical Society’s Green Chemistry Institute Pharmaceutical Roundtable. Here, we report an organocatalyst that can achieve the synthesis of amides at room temperature. The catalyst includes both boronic acid and phosphine oxide functionalities, which operate in concert to facilitate substrate activation. Unlike that of other arylboronic acid catalysts, the monomeric mechanism proceeds via a redox-neutral phosphorus(V) cycle, where the adjacent boronic acid is key to room-temperature activity.

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来源期刊

Chem Catalysis

CiteScore

10.50

自引率

6.40%

发文量

期刊介绍： Chem Catalysis is a monthly journal that publishes innovative research on fundamental and applied catalysis, providing a platform for researchers across chemistry, chemical engineering, and related fields. It serves as a premier resource for scientists and engineers in academia and industry, covering heterogeneous, homogeneous, and biocatalysis. Emphasizing transformative methods and technologies, the journal aims to advance understanding, introduce novel catalysts, and connect fundamental insights to real-world applications for societal benefit.