癌症死亡率和衰老：氧化还原治疗是一种选择吗？

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-07-14 DOI:10.1101/gad.353129.125

Shan Kuang, Manojit M. Swamynathan, Lloyd C. Trotman

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引用次数: 0

摘要

患者基因组学和小鼠功能遗传学显示衰老是前列腺癌转移进展的障碍。许多努力集中于消除衰老细胞，而另一些则旨在阐明使它们区别于正常细胞和衰老细胞的独特特征。在这里，我们讨论了探索衰老细胞的氧化还原状态如何有助于定义新的标记物和促氧化脆弱性，类比于已知的增殖癌细胞的氧化还原敏感性。

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Cancer mortality and senescence: Is redox therapy an option?

Patient genomics and mouse functional genetics have revealed that senescence is a barrier to metastatic progression of prostate cancer. Many efforts focus on eliminating senescent cells, whereas others aim to elucidate distinct characteristics that set them apart from normal and aging cells. Here, we discuss how exploration of the redox state of senescent cells could help define new markers and pro-oxidant vulnerabilities, drawing analogy to what is known about the redox sensitivity of proliferating cancer cells.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).