EXPRESS:肾结石和输尿管结石的不同氧化应激谱:来自血清和尿液标志物的生化见解。

IF 2
Marek Biesiadecki, Krzysztof Balawender, Mateusz Mołoń, Agnieszka Mołoń, Sabina Galiniak
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引用次数: 0

摘要

尿石症的特点是在尿路内形成结石,这是一个重大的医学挑战,受多因素的影响,包括遗传易感性、饮食和生活方式因素。这种情况主要影响男性,并在全球不同地区表现出不同的患病率。氧化障碍通过涉及肾脏炎症和组织损伤的机制参与尿石症的发病机制。本研究调查了107例肾脏或输尿管结石患者和80例健康对照者的血清和尿液氧化还原标志物。据我们所知,这是比较肾结石和输尿管结石患者血清和尿液中氧化应激水平的初步研究。我们观察到高级氧化蛋白产物(AOPP, p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differential Oxidative Stress Profiles in Nephrolithiasis and Ureterolithiasis: Biochemical Insights From Serum and Urinary Markers.

Urolithiasis, characterized by the formation of stones within the urinary tract, poses a significant medical challenge influenced by multifactorial origins, including genetic predisposition, diet, and lifestyle factors. This condition predominantly affects males and exhibits varying prevalence rates across different global regions. Oxidative disturbances have been implicated in urolithiasis pathogenesis through mechanisms involving renal inflammation and tissue damage. This study investigated serum and urinary redox markers in 107 patients with kidney or ureteral stones vs 80 healthy controls. To the best of our knowledge, this represents the initial investigation comparing oxidative stress levels in the serum and urine of patients afflicted with nephrolithiasis and ureterolithiasis. We observed significantly elevated levels of advanced oxidation protein products (AOPP, p < 0.01), malondialdehyde (p < 0.001), total oxidant status (TOS, p < 0.001), and oxidative stress index (OSI, p < 0.001) in serum of urolithiasis patients, alongside decreased total antioxidant capacity (TAC, p < 0.001). There were no differences in thiol group and Amadori products concentrations between the studied groups. Moreover, increased concentration of AOPP (p < 0.001), TOS (p < 0.01), and OSI (p < 0.01), as well as decreased level of TAC (p < 0.001), were observed in the urine of urolithiasis patients. Distinct patterns of oxidative stress markers were observed between nephrolithiasis and ureterolithiasis subgroups, underscoring differential oxidative stress profiles in these conditions. These findings may support early diagnosis, risk stratification, and personalized management of urolithiasis patients by revealing distinct oxidative stress profiles associated with stone location (renal vs ureteral).

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