基于体素的阿尔茨海默病特定区域分析系统与脑磁共振成像中动脉自旋标记的比较研究。

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yukinori Okada, Norikazu Ohno, Yoshisuke Kitahara, Hirofumi Niioka, Koji Tanaka, Hiromitsu Ueda, Katsunori Tsujii, Masayuki Sato
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引用次数: 0

摘要

导语:磁共振成像利用基于体素的阿尔茨海默病特异性区域分析系统和动脉自旋标记,可以区分阿尔茨海默型痴呆和路易体痴呆。磁共振成像显示阿尔茨海默型痴呆患者从扣带回后部到楔前叶的血流量减少。然而,基于体素的特定区域分析系统评分与动脉自旋标记之间的关系尚不清楚。探讨脑萎缩评分与后扣带楔前叶动脉自旋标记值的关系。方法:采用基于体素的区域分析系统对疑似痴呆患者进行脑磁共振成像。分组如下:1组(疑似阿尔茨海默型痴呆)感兴趣体积萎缩≥2;结果:1、2、3组分别有179、143、197例患者。扣带后楔前叶动脉自旋标记值分别为77.0±24.4 ~ 77.3±25.2、78.3±81.3 ~ 80.2±23.6、80.2±22.3 ~ 80.4±22.8 mL/min/100 g。第1组脑萎缩总量与动脉自旋标记的相关系数为-0.189 ~ 0.214 (P)。讨论:在阿尔茨海默型痴呆和路易体痴呆中,扣带后回和楔前叶血流减少与脑萎缩仅呈弱相关。因此,它不是区分阿尔茨海默型痴呆与路易体痴呆等组痴呆的可靠标志。结论:在诊断痴呆时应避免单独使用脑血流量评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Voxel-Based Specific Regional Analysis System for Alzheimer's Disease and Arterial Spin Labeling in Brain Magnetic Resonance Imaging: A Comparative Study.

Introduction: Magnetic resonance imaging can differentiate Alzheimer-type dementia from dementia with Lewy bodies using voxel-based specific regional analysis systems for Alzheimer's disease and arterial spin labeling, which reveal reduced blood flow from the posterior cingulate gyrus to the precuneus in Alzheimer-type dementia. However, the relationship between voxel-based specific regional analysis system scores and arterial spin labeling remains unclear. To investigate the relationship between brain atrophy scores and arterial spin labeling values in the posterior cingulate precuneus.

Methods: Participants with suspected dementia who underwent brain magnetic resonance imaging using a voxel-based regional analysis system were included. They were classified as follows: Group 1 (suspected Alzheimer-type dementia) had atrophy ≥2 in the volume of interest; Group 2 (suspected dementia with Lewy body) had atrophy <2 in the volume of interest and ≥0.2 in the gray and white matter of the dorsal brainstem; and Group 3 included those not meeting these criteria. Correlation values among atrophy within the volume of interest, percentage of atrophic areas, atrophy ratio, percentage of total brain atrophy, age, and maximum arterial spin labeling value at the posterior cingulate precuneus were evaluated.

Results: Groups 1, 2, and 3 comprised 179, 143, and 197 patients, respectively. Arterial spin labeling values at the posterior cingulate precuneus were 77.0±24.4-77.3±25.2, 78.3±81.3-80.2±23.6, and 80.2±22.3-80.4±22.8 mL/min/100 g, respectively. Group 1 had a correlation coefficient between total brain atrophy and arterial spin labeling of -0.189 to-0.214 (P<0.01). Group 2 had a correlation coefficient between total brain atrophy and arterial spin labeling of -0.215 to -0.223 (P<0.01). Group 3 showed no significant correlations. No statistically significant difference was observed in ASL 1 and 2 values between the Alzheimer-type dementia and other groups (ASL 1: 74.5 mL/min/100 g vs. 78.8 mL/min/100 g, P=0.08; ASL 2: 74.8 mL/min/100 g vs. 79.2 mL/min/100 g, P=0.101). No statistically significant difference was observed in ASL 1 and 2 values between the Alzheimer-type dementia and DLB groups (ASL 1: 74.5 mL/min/100 g vs. 69.3. mL/min/100 g, P=0.093; ASL 2: 74.8 mL/min/100 g vs. 78.9 mL/min/100 g, P=0.258).

Discussion: Reduced blood flow in the posterior cingulate gyrus and precuneus shows only a weak correlation with brain atrophy in both Alzheimer-type dementia and dementia with Lewy bodies. Therefore, it is not a reliable marker for differentiating Alzheimer-type dementia from dementia with Lewy bodies and other groups.

Conclusion: It is necessary to avoid using cerebral blood flow assessment alone when diagnosing dementia.

.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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