三叶清作为IBD和CRC潜在治疗候选药物的潜在作用和有效成分。

IF 2.7 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
OncoTargets and therapy Pub Date : 2025-07-07 eCollection Date: 2025-01-01 DOI:10.2147/OTT.S516341
Chaoying Chen, Lin Chen, Weifeng Zheng, Yiyang Dai
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引用次数: 0

摘要

炎症性肠病(IBD)是一种慢性炎症性疾病,如克罗恩病(CD)和溃疡性结肠炎(UC)。在IBD可能引起的严重恶性肿瘤中,结直肠癌尤为普遍。患有IBD和CRC的个体通常会出现类似的症状,包括腹泻、直肠出血、腹部不适、体重下降和极度疲惫。三叶清是一种传统的草本药用植物,具有抗肿瘤、抗炎、镇痛、清热、解毒、护肝等作用。本文就IBD和CRC可能的分子机制进行综述,并对三叶清在IBD和CRC临床治疗中的潜在作用进行综述。研究肠炎和肠癌的病因,并探索三叶清作为预防和治疗药物的潜力,对对抗这些疾病至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC.

Inflammatory bowel disease (IBD) is a family of chronic inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC). Among the serious malignancies that can arise from IBD, colorectal cancer is particularly prevalent. Individuals suffering from both IBD and CRC often endure similar symptoms, which include diarrhea, rectal bleeding, abdominal discomfort, weight decline, and profound exhaustion. Sanyeqing is a traditional herbaceous medicinal plant with anti-tumor, anti-inflammatory, analgesic, heat-clearing, detoxifying, and liver-protecting effects. Here, we summarize the possible molecular mechanisms of IBD and CRC, and summarize the potential role of Sanyeqing in clinical therapy for IBD and CRC. Investigating the etiology of enteritis and intestinal cancer, as well as exploring Sanyeqing's potential as a preventive and therapeutic agent, is of paramount importance in the battle against these diseases.

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来源期刊
OncoTargets and therapy
OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY
CiteScore
9.70
自引率
0.00%
发文量
221
审稿时长
1 months
期刊介绍: OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.
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