Richard Dagher, Megan C Jacobsen, Satvik Vasireddy, Rick R Layman, Dong-Eog Kim, Max Wintermark, Dawid Schellingerhout
{"title":"双能CT与单能CT对脑内红细胞压积和血红蛋白的评估：体内分析。","authors":"Richard Dagher, Megan C Jacobsen, Satvik Vasireddy, Rick R Layman, Dong-Eog Kim, Max Wintermark, Dawid Schellingerhout","doi":"10.1007/s00234-025-03700-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Hematocrit (Hct) and hemoglobin (HB) levels in blood are known to be correlated with vascular attenuation values on single-energy computed tomography (SECT). Dual-energy computed tomography (DECT) is likely to have even better correlations than SECT, given its richer information content, but this remains unproven clinically. We compare and contrast DECT and SECT correlations between attenuation in the superior sagittal sinus (SSS) to patient Hct/HB levels, and explore the use of iodine/water decomposition maps for the same purpose.</p><p><strong>Methods: </strong>Brain SECT and DECT were acquired contemporaneously in 83 patients and attenuation was measured in the SSS on SECT, monoenergetic DECT images (40 to 140 keV in 5 keV increments) and DECT material decomposition images (water and iodine). Hct/HB values were from complete blood counts (CBC) within 30 days of imaging. Linear regressions were performed to Hct/HB using the measured attenuations as explanatory variables.</p><p><strong>Results: </strong>Hct and HB were strongly mutually correlated (r = 0.964). Hct/HB were moderately correlated (r = 0.493/0.458) with SSS attenuation on SECT, and moderately to strongly correlated for DECT (Pearson's r ranging 0.331-0.656) over a range of monoenergetic levels (40 to 140 keV). Above 60 keV, DECT monoenergetic images were better correlated to Hct/HB than SECT, with correlation maximized at 95 keV (r = 0.656, p < 0.001). Material decomposition water images had moderate correlation (r = 0.51), improving to strong correlation (r = 0.659) for a two-variable water and iodine regression, similar to the monoenergetic results.</p><p><strong>Conclusion: </strong>DECT has better correlations to Hct/HB than SECT for all monoenergetic energies above 60 keV, with best correlations at 95 keV.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dual- energy CT versus single-energy CT for estimation of hematocrit and hemoglobin in the brain: an in vivo analysis.\",\"authors\":\"Richard Dagher, Megan C Jacobsen, Satvik Vasireddy, Rick R Layman, Dong-Eog Kim, Max Wintermark, Dawid Schellingerhout\",\"doi\":\"10.1007/s00234-025-03700-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Hematocrit (Hct) and hemoglobin (HB) levels in blood are known to be correlated with vascular attenuation values on single-energy computed tomography (SECT). Dual-energy computed tomography (DECT) is likely to have even better correlations than SECT, given its richer information content, but this remains unproven clinically. We compare and contrast DECT and SECT correlations between attenuation in the superior sagittal sinus (SSS) to patient Hct/HB levels, and explore the use of iodine/water decomposition maps for the same purpose.</p><p><strong>Methods: </strong>Brain SECT and DECT were acquired contemporaneously in 83 patients and attenuation was measured in the SSS on SECT, monoenergetic DECT images (40 to 140 keV in 5 keV increments) and DECT material decomposition images (water and iodine). Hct/HB values were from complete blood counts (CBC) within 30 days of imaging. Linear regressions were performed to Hct/HB using the measured attenuations as explanatory variables.</p><p><strong>Results: </strong>Hct and HB were strongly mutually correlated (r = 0.964). Hct/HB were moderately correlated (r = 0.493/0.458) with SSS attenuation on SECT, and moderately to strongly correlated for DECT (Pearson's r ranging 0.331-0.656) over a range of monoenergetic levels (40 to 140 keV). Above 60 keV, DECT monoenergetic images were better correlated to Hct/HB than SECT, with correlation maximized at 95 keV (r = 0.656, p < 0.001). Material decomposition water images had moderate correlation (r = 0.51), improving to strong correlation (r = 0.659) for a two-variable water and iodine regression, similar to the monoenergetic results.</p><p><strong>Conclusion: </strong>DECT has better correlations to Hct/HB than SECT for all monoenergetic energies above 60 keV, with best correlations at 95 keV.</p>\",\"PeriodicalId\":19422,\"journal\":{\"name\":\"Neuroradiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00234-025-03700-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03700-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Dual- energy CT versus single-energy CT for estimation of hematocrit and hemoglobin in the brain: an in vivo analysis.
Purpose: Hematocrit (Hct) and hemoglobin (HB) levels in blood are known to be correlated with vascular attenuation values on single-energy computed tomography (SECT). Dual-energy computed tomography (DECT) is likely to have even better correlations than SECT, given its richer information content, but this remains unproven clinically. We compare and contrast DECT and SECT correlations between attenuation in the superior sagittal sinus (SSS) to patient Hct/HB levels, and explore the use of iodine/water decomposition maps for the same purpose.
Methods: Brain SECT and DECT were acquired contemporaneously in 83 patients and attenuation was measured in the SSS on SECT, monoenergetic DECT images (40 to 140 keV in 5 keV increments) and DECT material decomposition images (water and iodine). Hct/HB values were from complete blood counts (CBC) within 30 days of imaging. Linear regressions were performed to Hct/HB using the measured attenuations as explanatory variables.
Results: Hct and HB were strongly mutually correlated (r = 0.964). Hct/HB were moderately correlated (r = 0.493/0.458) with SSS attenuation on SECT, and moderately to strongly correlated for DECT (Pearson's r ranging 0.331-0.656) over a range of monoenergetic levels (40 to 140 keV). Above 60 keV, DECT monoenergetic images were better correlated to Hct/HB than SECT, with correlation maximized at 95 keV (r = 0.656, p < 0.001). Material decomposition water images had moderate correlation (r = 0.51), improving to strong correlation (r = 0.659) for a two-variable water and iodine regression, similar to the monoenergetic results.
Conclusion: DECT has better correlations to Hct/HB than SECT for all monoenergetic energies above 60 keV, with best correlations at 95 keV.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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