Omicron COVID-19和心脏生物标志物升高患者的长期心血管结局:中国上海的一项前瞻性多中心队列研究

IF 3.2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
International Journal of Medical Sciences Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI:10.7150/ijms.112282
Shun Yao, Yamei Xu, Zhonglei Xie, Shuai Yuan, Junqing Gao, Qianwei Chen, Kailei Shi, Zongjun Liu, Xiaotong Cui, Yanyan Wang, Yu Song, Xueting Han, Junbo Ge, Zhenju Song, Jingmin Zhou
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引用次数: 0

摘要

背景:SARS-CoV-2组粒感染患者的长期心血管结局尚不清楚。本研究旨在评估心脏生物标志物升高的住院ommicron感染患者的急性和长期心血管风险。方法:我们纳入了2022年12月1日至2023年1月31日在中国上海住院的3012例患者。根据心脏肌钙蛋白T (cTnT)和n端前b型利钠肽(NT-proBNP)水平将参与者分为四组。在12个月的随访中评估主要不良心血管事件(mace)、全因死亡、心血管死亡和心血管相关再住院。结果:cTnT升高和NT-proBNP高的患者发生mace (HRadj=2.85, 95% CI 1.58-5.12)、全因死亡(HRadj=5.56, 95% CI 1.51-20.52)、心血管死亡(HRadj=11.97, 95% CI 1.40-102.46)和心血管相关再住院(HRadj=2.38, 95% CI 1.28-4.42)的风险显著升高。亚组分析的结果表明,mace的风险与年龄、性别、高血压、冠状动脉疾病、急性冠状动脉综合征或心力衰竭无关。结论:在组粒感染的急性期,cTnT和NT-proBNP水平升高预示着12个月内不良心血管结局的风险显著增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term Cardiovascular Outcomes in Patients with Omicron COVID-19 and Elevated Cardiac Biomarkers: A Prospective Multicenter Cohort Study in Shanghai, China.

Background: The long-term cardiovascular outcomes of SARS-CoV-2 omicron-infected patients remain unclear. This study aimed to evaluate acute and long-term cardiovascular risks in hospitalized omicron-infected patients with elevated cardiac biomarkers. Methods: We included 3012 patients hospitalized in Shanghai, China, between December 1, 2022, and January 31, 2023. Participants were stratified into four groups based on cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Major adverse cardiovascular events (MACEs), all-cause death, cardiovascular death, and cardiovascular-related rehospitalization were evaluated over a 12-month follow-up. Results: Patients with elevated cTnT and high NT-proBNP had significantly higher risks of MACEs (HRadj=2.85, 95% CI 1.58-5.12), all-cause death (HRadj=5.56, 95% CI 1.51-20.52), cardiovascular death (HRadj=11.97, 95% CI 1.40-102.46), and cardiovascular-related rehospitalization (HRadj=2.38, 95% CI 1.28-4.42). The finding of Subgroup analyses indicated the risk of MACEs were independent of age, gender, hypertension, coronary artery disease, acute coronary syndrome, or heart failure. Conclusions: Elevated cTnT and NT-proBNP levels during the acute phase of omicron infection predict a substantially increased risk of adverse cardiovascular outcomes within 12 months.

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来源期刊
International Journal of Medical Sciences
International Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
7.20
自引率
0.00%
发文量
185
审稿时长
2.7 months
期刊介绍: Original research papers, reviews, and short research communications in any medical related area can be submitted to the Journal on the understanding that the work has not been published previously in whole or part and is not under consideration for publication elsewhere. Manuscripts in basic science and clinical medicine are both considered. There is no restriction on the length of research papers and reviews, although authors are encouraged to be concise. Short research communication is limited to be under 2500 words.
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