Pharmacological Potential of Coriander Seeds: A Dual Action Agent Against LPS of Pseudomonas aeruginosa (ATCC 27853) and an Epidermoid Carcinoma Cell Line.

Antimicrobial resistance is gaining a strong foothold in the current healthcare scenario, where skin infections caused by resistant strains of bacteria such as Pseudomonas aeruginosa are unresponsive to a majority of antibiotics. In light of this, there is a pressing need to develop novel strategies to control these pathogens. In this study, we aimed to investigate the antibacterial and antiproliferative activities of the bioactive compounds present in the methanolic extract of Coriandrum sativum seeds. The extract, characterized by GC/MS, exhibited distinct antimicrobial activity (bacteriostatic) against Pseudomonas aeruginosa (ATCC 27853), with a maximum inhibition zone of 30 mm, minimum inhibitory concentration at 1.5625 mg/mL (0.25%) of antimicrobial agent, and decreased cell viability, size, and motility. As Coriandrum sativum is established to cause cell-disruption, we probed the action of the extract on lipopolysaccharide (LPS), a major component in the cell wall, acting as a virulence factor in Pseudomonas aeruginosa (ATCC 27853). Investigations revealed that the extract disrupted LPS, resulting in a significant reduction in LPS-induced inflammation in the A431 epidermoid carcinoma cell line. Additionally, the methanolic extract demonstrated antiproliferative activity, as evidenced by a decrease in cell viability. Our findings provide novel mechanistic insights into the activity of the extract on LPS, and warrant further investigation into its antiproliferative potential.

Supplementary information: The online version contains supplementary material available at 10.1007/s12088-024-01399-z.