{"title":"微生物精炼厂：生产多用途短链有机酸的工程微生物。","authors":"Anuradha Singh, Javeria, Kavya Singh, Udit Kumar","doi":"10.1007/s12088-025-01465-0","DOIUrl":null,"url":null,"abstract":"<p><p>Microbial bio-refineries offer a sustainable alternative to traditional petrochemical methods for organic acid production by harnessing the metabolic capabilities of microorganisms to convert renewable feed-stocks into valuable products. This review aims to provide an overview of recent advancements in metabolic engineering techniques that have significantly enhanced the efficiency and productivity of microbial organic acid production. The review discusses key strategies, including pathway engineering, strain optimization, and process optimization, that have contributed to the development of these bio-refineries. Furthermore, it highlights the potential of microbial bio-refineries for sustainable bio-based manufacturing, emphasizing their role in reducing reliance on fossil fuels and promoting a circular economy. This review will serve as a valuable resource for researchers and industry professionals seeking to advance the development of sustainable and economically viable microbial biorefineries for the production of organic acids.</p>","PeriodicalId":13316,"journal":{"name":"Indian Journal of Microbiology","volume":"65 2","pages":"645-667"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246302/pdf/","citationCount":"0","resultStr":"{\"title\":\"Microbial Bio-refineries: Engineering Microbes for the Production of Versatile Short-Chain Organic Acids.\",\"authors\":\"Anuradha Singh, Javeria, Kavya Singh, Udit Kumar\",\"doi\":\"10.1007/s12088-025-01465-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Microbial bio-refineries offer a sustainable alternative to traditional petrochemical methods for organic acid production by harnessing the metabolic capabilities of microorganisms to convert renewable feed-stocks into valuable products. This review aims to provide an overview of recent advancements in metabolic engineering techniques that have significantly enhanced the efficiency and productivity of microbial organic acid production. The review discusses key strategies, including pathway engineering, strain optimization, and process optimization, that have contributed to the development of these bio-refineries. Furthermore, it highlights the potential of microbial bio-refineries for sustainable bio-based manufacturing, emphasizing their role in reducing reliance on fossil fuels and promoting a circular economy. This review will serve as a valuable resource for researchers and industry professionals seeking to advance the development of sustainable and economically viable microbial biorefineries for the production of organic acids.</p>\",\"PeriodicalId\":13316,\"journal\":{\"name\":\"Indian Journal of Microbiology\",\"volume\":\"65 2\",\"pages\":\"645-667\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246302/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12088-025-01465-0\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12088-025-01465-0","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Microbial Bio-refineries: Engineering Microbes for the Production of Versatile Short-Chain Organic Acids.
Microbial bio-refineries offer a sustainable alternative to traditional petrochemical methods for organic acid production by harnessing the metabolic capabilities of microorganisms to convert renewable feed-stocks into valuable products. This review aims to provide an overview of recent advancements in metabolic engineering techniques that have significantly enhanced the efficiency and productivity of microbial organic acid production. The review discusses key strategies, including pathway engineering, strain optimization, and process optimization, that have contributed to the development of these bio-refineries. Furthermore, it highlights the potential of microbial bio-refineries for sustainable bio-based manufacturing, emphasizing their role in reducing reliance on fossil fuels and promoting a circular economy. This review will serve as a valuable resource for researchers and industry professionals seeking to advance the development of sustainable and economically viable microbial biorefineries for the production of organic acids.
期刊介绍：
Indian Journal of Microbiology is the official organ of the Association of Microbiologists of India (AMI). It publishes full-length papers, short communication reviews and mini reviews on all aspects of microbiological research, published quarterly (March, June, September and December). Areas of special interest include agricultural, food, environmental, industrial, medical, pharmaceutical, veterinary and molecular microbiology.
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