肝脏疾病中线粒体自噬的机制及调控研究进展。

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1614940

Sen Liu, Libo Wang, Liuyang Zhu, Tianyu Zhao, Pinsheng Han, Fengying Yan, Xiaoliang Wang, Chunli Li, Ze Wang, Bao-Feng Yang

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引用次数: 0

摘要

线粒体对健康真核细胞的正常运作至关重要。线粒体自噬是一种特殊形式的自噬，以受损或多余的线粒体为目标，在肝脏的正常功能和疾病相关过程中都起着关键作用。本文旨在探讨线粒体自噬启动的主要机制及其在各种肝脏疾病中的重要性，如酒精性肝病、药物性肝损伤、非酒精性脂肪性肝病、病毒性肝炎和癌症。深入了解这些机制可以帮助克服在临床实践中利用线粒体自噬作为治疗策略的障碍。

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Mechanism and regulation of mitophagy in liver diseases: a review.

Mitochondria are vital for the proper operation of healthy eukaryotic cells. Mitophagy, a specialized form of autophagy that targets damaged or surplus mitochondria, plays a key role in both the normal functioning and disease-related processes within the liver. This review aims to explore the main mechanisms underlying the initiation of mitophagy and its importance in various liver conditions, such as alcoholic liver disease, drug-induced liver injury, non-alcoholic fatty liver disease, viral hepatitis, and cancer. Gaining insight into these mechanisms can help overcome the obstacles related to harnessing mitophagy as a therapeutic strategy in clinical practice.

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.