顺式异丙酸通过调节哺乳动物的食物摄入和脂质代谢而具有抗肥胖作用

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-07-14 DOI:10.1016/j.jff.2025.106958

Yuchan Wen , Ruihan Zhang , Jiatong Xie, Ailin Wan, Shuozheng Mei, Jiwei Xie, Shuyi Lei, Qingyou Xia, Genhong Wang

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引用次数: 0

摘要

顺式异丙酸已被证明可以调节家蚕的食物摄入，但其在哺乳动物中的潜在作用尚不清楚。在本研究中，小鼠分别饲喂标准脂肪和高脂肪饲料，并添加顺式异丙酸，以评估其对饱腹调节和相关生理生化参数的影响。结果表明，顺式异丙酸通过显著上调胆囊收缩素和肽酪氨酸酪氨酸的表达来增强小鼠的饱足感，最终导致体重增加减少16.1%，食物摄入量减少34.1%。qRT-PCR分析显示，顺式异丙酸管理下调肝脏脂肪生成相关基因（ACC、SREBP-1a、FAS和SCD-1/SCD-2），上调脂质分解代谢相关基因（PPARα和CPT-1）。组织学评估显示，补充顺式异丙酸能有效减轻hfd诱导的肝脏脂肪变性和脂肪细胞肥大。顺式异戊酸处理小鼠未见明显毒性。这些发现表明顺式异丙酸可能是肥胖管理和相关代谢紊乱的新治疗靶点。

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Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals

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Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals

Cis-vaccenic acid has been shown to regulate food intake in Bombyx mori, but its potential role in mammals remains unclear. In this study, mice were fed either standard or high-fat diets supplemented with cis-vaccenic acid to evaluate its effects on satiety regulation and related physiological/biochemical parameters. The results demonstrated that dietary cis-vaccenic acid enhanced satiation in mice through significant upregulation of cholecystokinin and peptide tyrosine tyrosine expression, ultimately leading to a 16.1 % reduction in weight gain and 34.1 % decrease in food intake. qRT-PCR analysis revealed that cis-vaccenic acid administration downregulated hepatic lipogenesis-related genes (ACC, SREBP-1a, FAS, and SCD-1/SCD-2) while upregulating lipid catabolism-associated genes (PPARα and CPT-1). Histological evaluations showed that cis-vaccenic acid supplementation effectively mitigated HFD-induced hepatic steatosis and adipocyte hypertrophy. No detectable toxicity was observed in cis-vaccenic acid-treated mice. These findings suggest that cis-vaccenic acid may represent a novel therapeutic target for obesity management and related metabolic disorders.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.