从免疫抑制到自身免疫：免疫抑制肝移植患者的ANCA-PR3+血管炎。案例报告

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-07-01 DOI:10.1016/j.rcreu.2024.05.005

Oscar Vicente Vergara Serpa , Carlos Jaime Velásquez-Franco , Luis Fernando Pinto , Neil Smith Pertuz Charris , Andrés Felipe Echeverri García , Alejandro Cardona Palacio , Javier Darío Márquez Hernández

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引用次数: 0

摘要

目的报告一例免疫抑制患者发展为自身免疫性疾病。患者和方法：30岁女性，因原位肝移植史免疫抑制，并发巨细胞病毒肠道感染和肺泡出血。结果患者PR3 ANCA血清学阳性，归类为肉芽肿合并多血管炎。由于她的病史，我们考虑了诱导和抗cd20维持，在6个月的随访中没有进一步复发。结论免疫抑制患者存在发生自身免疫性疾病的危险因素。

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查看原文本刊更多论文

De la inmunosupresión a la autoinmunidad: vasculitis ANCA-PR3+ en una paciente inmunosuprimida por trasplante hepático. Reporte de un caso

Objective

To present the case of an immunosuppressed patient who developed an autoimmune disease.

Patients and methods

30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage.

Results

Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up.

Conclusion

Immunosuppressed patients have risk factors for developing autoimmune diseases.

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.