长冠状病毒报告持续认知抱怨的个人概况。

Carmen Cabello Fernandez, Vincent Didone, Hichem Slama, Gilles Dupuis, Patrick Fery, Gaël Delrue, Alexia Lesoinne, Fabienne Collette, Sylvie Willems
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引用次数: 0

摘要

目的:一部分COVID-19患者在感染后24个月仍存在认知困难。导致这些症状的因素是复杂的,潜在的病理生理尚不清楚。本研究旨在描述长COVID报告认知问题的个体。方法:根据随机对照试验(COVCOG)的基线,对123例患者进行了全面的神经心理学评估,同时对认知抱怨、疲劳、睡眠困难、生活质量、心理困扰和对日常活动的影响进行了问卷调查。对认知评分进行潜在特征分析,以调查不同患者特征的存在。方差分析和皮尔逊卡方检验了这些概况对人口统计变量和问卷得分的影响。结果:患者以轻中度感染为主(87.8%),平均在感染后20.9(±8.6)个月进行评估。神经心理学评估显示72%的患者至少有一个领域的认知障碍,主要是注意力和执行功能。超过80%的人报告有睡眠问题和疲劳,97%的人有注意力问题,约80%的人有记忆和找词问题。自我报告问卷也显示了明显的抱怨。结论:该研究确定了长COVID患者的三种不同特征,强调需要进行综合评估,包括神经心理、心理、躯体和功能方面的评估,以实施有效的、量身定制的干预措施。Clinicaltrials.gov: NCT05167266。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.

Objective: A subset of COVID-19 patients continues to experience cognitive difficulties 24 months post-infection. The factors driving these symptoms are complex, and the underlying pathophysiology is unclear. This study aimed to characterize individuals with Long COVID reporting cognitive issues.

Method: One hundred twenty-three patients underwent a comprehensive neuropsychological evaluation resulting from the baseline of an RCT study (COVCOG), along with questionnaires assessing cognitive complaints, fatigue, sleep difficulties, quality of life, psychological distress, and impact on daily activities. Latent Profile Analyses on cognitive scores were conducted to investigate the presence of different patient profiles. Robust analyses of variance and Pearson's chi-square examined the profiles' effects on demographic variables and questionnaire scores.

Results: Patients had had predominantly mild to moderate infections (87.8%) and were assessed an average of 20.9 (±8.6) months post-infection. Neuropsychological assessment showed cognitive impairment in at least one domain in 72% of the patients, mainly in attention and executive functions. Over 80% reported sleep problems and fatigue, 97% concentration problems, and some 80% memory and word-finding problems. The self-report questionnaires also revealed significant complaints. Three profiles emerged (all ps < .001). Profiles 1 and 2 both experienced widespread cognitive issues; Profile 1 patients expressed more complaints about cognitive functioning and daily fatigue (all ps < .045). Patients in Profile 3 were more frequently men (all ps < .049) with a specific impairment of verbal long-term memory and fewer complaints.

Conclusions: The study identifies three different profiles of individuals with Long COVID, highlighting the need for comprehensive evaluations including neuropsychological, psychological, somatic, and functional aspects to implement effective, tailored interventions. Clinicaltrials.gov: NCT05167266.

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