Yihui Yang, Emma Bränn, Jing Zhou, Dang Wei, Jacob Bergstedt, Fang Fang, Unnur A Valdimarsdóttir, Elizabeth Bertone-Johnson, Donghao Lu
{"title":"经前紊乱和心血管疾病的风险。","authors":"Yihui Yang, Emma Bränn, Jing Zhou, Dang Wei, Jacob Bergstedt, Fang Fang, Unnur A Valdimarsdóttir, Elizabeth Bertone-Johnson, Donghao Lu","doi":"10.1038/s44161-025-00684-4","DOIUrl":null,"url":null,"abstract":"<p><p>Several lines of evidence indicate a potential link between premenstrual disorders (PMDs) and cardiovascular diseases (CVDs). However, it remains unclear whether women with PMDs have a higher risk of CVDs. Here we present a Swedish nationwide population-based matched cohort study from 2001 to 2022 and a sibling matched cohort to address familial confounding. A total of 99,411 women with PMDs were included in the population analysis and 36,061 women with PMDs in the sibling analysis. Compared with individuals without PMDs, women with PMDs had a higher risk of any CVD (adjusted hazard ratio = 1.11 (95% confidence interval: 1.08-1.13) in the population analysis and 1.10 (95% confidence interval: 1.06-1.15) in the sibling analysis). The risk was particularly pronounced for PMDs diagnosed before 25 years of age and PMDs with comorbid perinatal depression. Our study shows that women who received a PMD diagnosis in specialist or primary care are at a higher risk of CVDs.</p>","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":" ","pages":""},"PeriodicalIF":10.8000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Premenstrual disorders and risk of cardiovascular diseases.\",\"authors\":\"Yihui Yang, Emma Bränn, Jing Zhou, Dang Wei, Jacob Bergstedt, Fang Fang, Unnur A Valdimarsdóttir, Elizabeth Bertone-Johnson, Donghao Lu\",\"doi\":\"10.1038/s44161-025-00684-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Several lines of evidence indicate a potential link between premenstrual disorders (PMDs) and cardiovascular diseases (CVDs). However, it remains unclear whether women with PMDs have a higher risk of CVDs. Here we present a Swedish nationwide population-based matched cohort study from 2001 to 2022 and a sibling matched cohort to address familial confounding. A total of 99,411 women with PMDs were included in the population analysis and 36,061 women with PMDs in the sibling analysis. Compared with individuals without PMDs, women with PMDs had a higher risk of any CVD (adjusted hazard ratio = 1.11 (95% confidence interval: 1.08-1.13) in the population analysis and 1.10 (95% confidence interval: 1.06-1.15) in the sibling analysis). The risk was particularly pronounced for PMDs diagnosed before 25 years of age and PMDs with comorbid perinatal depression. Our study shows that women who received a PMD diagnosis in specialist or primary care are at a higher risk of CVDs.</p>\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s44161-025-00684-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44161-025-00684-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Premenstrual disorders and risk of cardiovascular diseases.
Several lines of evidence indicate a potential link between premenstrual disorders (PMDs) and cardiovascular diseases (CVDs). However, it remains unclear whether women with PMDs have a higher risk of CVDs. Here we present a Swedish nationwide population-based matched cohort study from 2001 to 2022 and a sibling matched cohort to address familial confounding. A total of 99,411 women with PMDs were included in the population analysis and 36,061 women with PMDs in the sibling analysis. Compared with individuals without PMDs, women with PMDs had a higher risk of any CVD (adjusted hazard ratio = 1.11 (95% confidence interval: 1.08-1.13) in the population analysis and 1.10 (95% confidence interval: 1.06-1.15) in the sibling analysis). The risk was particularly pronounced for PMDs diagnosed before 25 years of age and PMDs with comorbid perinatal depression. Our study shows that women who received a PMD diagnosis in specialist or primary care are at a higher risk of CVDs.