Agustín Robles-Remacho, Yimin Zou, Marco Grillo, Mats Nilsson
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Spatially resolved microRNA expression in tissues: technologies, challenges, and opportunities.
As the field of spatial omics continues to expand, the spatially resolved profiling of microRNA (miRNA) expression in tissues, or 'spatial miRNomics,' remains in its infancy, with only a few initial pioneering studies to date. MiRNA expression exhibits distinct spatial, temporal, and cell type-specific patterns, and the dysregulation of these patterns is associated with numerous pathological conditions. This highlights the potential of miRNAs as targets for spatial transcriptomic studies in translational and clinical research. In this review, we examine the current landscape of spatial technologies for miRNA detection from foundational methods to cutting-edge innovations, and we discuss conceptual and technical challenges. We also outline the biomedical implications of spatial miRNA profiling and set out future directions for exploring the spatial dimension of gene regulation.
期刊介绍：
Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology.
Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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