Xiwen Yan, Bo Chen, Xinyue Song, Ying Zhou, Feng Jin, Ang Zheng
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Mechanisms of snoRNAs in cancer treatment resistance: from molecular insights to clinical applications.
Small nucleolar RNAs (snoRNAs), traditionally regarded as guides for RNA modification, have emerged as critical regulators of tumor progression and treatment resistance. This review comprehensively outlines the roles of snoRNAs and their host genes in mediating cancer treatment resistance, with an emphasis on mechanisms involving epigenetic regulation, metabolic reprogramming, and tumor microenvironment (TME) remodeling. It further explores their potential as predictive biomarkers for cancer diagnosis, prognosis, and treatment response. In addition, the review addresses current technical challenges related to detection standardization and clinical translation. Future research is expected to establish a solid theoretical foundation and practical strategies to overcome drug resistance and promote the development of personalized cancer therapy.
期刊介绍：
Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology.
Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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